十全大补汤加味联合空肠营养管改善胃恶性肿瘤患者疗效观察

Observation on the Efficacy of Modified Shiquan Dabu Decoction Combined with Jejunum Nutrition Tube in Improving Patients with Gastric Malignant Tumor

目的观察十全大补汤加味联合空肠营养管在胃恶性肿瘤患者短期营养状况改善中的作用。方法将115例符合纳入标准的患者,随机分为治疗组(空肠营养管置入+十全大补汤加味+肠内营养制剂支持,57例)、对照组(肠内营养制剂支持,58例)。分别于第4周末、第8周末、第12周末复查血红蛋白、白蛋白指标,同时采用Karnofsky功能状态(KPS)、营养风险筛查量表(NRS2002)进行评分。结果血红蛋白在各时间点差异有统计学意义(P<0.05),在第8周末、第12周末比较有统计学差异(P<0.05)。白蛋白治疗组分别在各时间点的差异均有统计学意义(P<0.05)。对照组白蛋白分别在治疗前、第4周末、第8周末两两比较的差异均有统计学意义(P<0.05)。治疗组与对照组白蛋白在第4周末、第8周末、第12周末比较均有统计学差异(P<0.05)。治疗组KPS评分在各时间的差异均有统计学意义(P<0.05)。对照组KPS评分分别在治疗前与第4周末,第4周末与第8周末,第4周末与第12周末,第8周末与第12周末比较均有统计学差异(P<0.05)。治疗组与对照组KPS评分分别在第4周末、第8周末、第12周末两两比较均有统计学差异(P<0.05)。营养风险筛查量表治疗组分别在治疗前与第4周末、第8周末、第12周末比较,第4周末与第12周末比较的差异均有统计学意义(P<0.05)。对照组营养风险筛查量表评分在治疗前与第12周末比较均有统计学差异(P<0.05)。结论十全大补汤加味联合空肠营养管能有效纠正患者低白蛋白及贫血状态,并能改善KPS及营养风险评分,具有积极临床意义。

Objective To observe the effect of Shiquan Dabu Decoction combined with jejunal nutrition tube on shortterm improvement of nutritional status of patients with gastric malignant tumor.Methods A total of 115 patients who met the inclusion criteria were randomly divided into the treatment group(jejunal nutrition tube placement+Shiquan dabu Decoction addition+enteral nutrition preparation support,57 cases)and the control group(enteral nutrition preparation support,58 cases).Hemoglobin and albumin indexes were reviewed at the end of 4,8 and 12,respectively.At the same time,Karnofsky functional status(KPS)and nutritional risk screening scale(NRS2002)were used for scoring.Results There were statistically significant differences in hemoglobin at each time point(P<0.05),and there were statistically significant differences at the end of the 8^(th)week and the end of the 12^(th)week(P<0.05).Pairwise comparisons of the albumin treatment group at each time point were statistically significant(P<0.05).The difference of albumin in the control group before treatment,at the end of the 4^(th)week and the end of the 8^(th)week was statistically significant(P<0.05).There were statistically significant differences in albumin between the treatment group and the control group at the weekend of 4,8 and 12(P<0.05).The pairwise comparison of KPS scores in the treatment group at each time point was statistically significant(P<0.05).The KPS score of the control group was statistically different from that of the 4^(th)weekend,the 4^(th)weekend and the 8^(th)weekend,the 4^(th)weekend and the 12^(th)weekend,and the 8^(th)weekend and the 12^(th)weekend before treatment(P<0.05).There were statistically significant differences in KPS scores between the treatment group and the control group at the end of the 4^(th)week,the 8^(th)week and the 12 thweek,respectively(P<0.05).The nutritional risk screening scale treatment group was compared with weekend 4,weekend 8 and weekend 12 before treatment,and the differences between weekend 4 and weekend 12 were statistically significant(P<0.05).There were statistically significant differences between the nutritional risk screening scale scores of the control group before treatment and at the end of the 12^(th)week(P<0.05).Conclusion The combination of Shiquan Dabu Decoction and jejunal nutrition tube can effectively correct the low albumin and anemia status of patients,and improve KPS and nutritional risk score,which has positive clinical significance.