大白鼠交感神经节内神经肽Y(NPY)样神经元的分布及其功能意义

DISTRIBUTION AND FUNCTION OF NPY IMMUNOREACTIVE NEURONS IN THE SYMPATHETIC GANGLIA OF RAT

本文用免疫细胞化学技术研究了大白鼠交感神经的颈上节,星状节,脑部和腹部的交感干节,腹腔节以及肠系膜上、下节内的NPY样免疫反应细胞体的分布。发现NPY样免疫反应细胞体为圆形或椭圆形。NPY样免疫反应产物呈颗粒状分布于细胞质中,多数交感神经节内的免疫反应细胞聚集成群,但椎前神经节内的NPY样免疫反应细胞较分散。本文并讨论了NPY存在于外周去甲肾上腺素能细胞中;NPY可以抑制由于电刺激引起的大白鼠输精管痉挛;局部动脉灌流可引起动脉收缩等问题。本文认为交感神经节中含有的NPY样免疫反应神经元与外周去甲肾上腺素能神经元为同一神经元。NPY对交感神经可能有兴奋或抑制功能。

The distribution of NPY immunoreactive cell bodies in the sympathetic ganglion of rat was investigated using immunocytochemical method.Neuropepride Y-l ke immunoreactivity(NPY-IR)is observed in the sympathetic paravertebral ganglion,sympathetic prevertebral ganglion,superior cervical ganglion,stellate ganglion,thoracic and abdominal sympathetic ganglia;coeliac,superior andinferior mesenteric ganglia.NPY-IR cell bodies were round or oval.The NPY-containing ganglion cells were characterized by a cytoplasmic staining which appeared granular at high magnification.NPYIR cell bodies were abundant in most sympathetic ganglia but lower in number in prevertebral ganglion.The following was reviewed and discussed.NPY-like immunoreactivity was found in many peripheral sympathetic noradrenergic neurons.NPY caused an inhibition of electrically induced contraction of the rat vas deferens and caused vasoconstriction by infusion with NPY.In conclusion,NPY-containing sympathetic ganglionic cells are the same neurons with peripheral noradrenergic neurons.NPY may play both excitatory and inhibitory effects on sympathetic function.