孟鲁司特钠联合特布他林雾化吸入治疗儿童咳嗽变异性哮喘伴肺炎支原体感染的疗效分析

Efficacy Analysis of Montelukast Sodium Combined with Terbutaline Inhalation in the Treatment of Children with Cough Variant Asthma with Mycoplasma Pneumoniae Infection

目的研究与分析孟鲁司特钠联合特布他林雾化吸入治疗儿童咳嗽变异性哮喘伴肺炎支原体感染的疗效。方法该次研究选取来该院进行治疗的患有儿童咳嗽变异性哮喘伴肺炎支原体感染疾病的患儿84例,研究对象选取时间段为2017年11月—2018年11月,随后按照就诊顺序将这84例患儿进行标号,其中单号患儿为特布他林组,双号患儿为联合治疗组,各42例。其中对特布他林组患儿采取单纯特布他林雾化吸入治疗,而对联合治疗组患儿采取孟鲁司特钠联合特布他林雾化吸入治疗,随后观察两组患儿治疗前后的患儿治疗前后的患儿治疗前后的最大呼气流量占正常预计值的百分比(PEF%)、1 s用力呼气容积(FEV1)以及1 s用力呼气容积占用力肺活量百分比(FEV1/FVC)等指标。结果联合治疗组与特布他林组患儿的PEF%、FEV1、FEV1/FVC以及治疗效果等指标均较佳,但是联合治疗组患儿的各项指标更佳[(96.73±4.53)%,(2.99±0.56)L,(71.89±3.88)%,97.6%VS(91.67±4.29)%,(2.71±0.66)L,(67.50±3.45)%,73.8%)],差异有统计学意义(t=5.256、2.096、5.480,χ~2=9.722,P<0.05)。结论孟鲁司特钠联合特布他林雾化吸入治疗儿童咳嗽变异性哮喘伴肺炎支原体感染的疗效显著,可以有效地提升治疗效果,值得进一步推广与使用。

Objective To study and analyze the efficacy of montelukast sodium combined with terbutaline inhalation in the treatment of children with cough variant asthma with Mycoplasma pneumoniae infection.Methods A total of 84 children with cough variant asthma and mycoplasma pneumoniae infection in the hospital were enrolled in this study.The study period was selected from November 2017 to November 2018,followed by the order of treatment.The 84 children were labelled.The single child was the terbutaline group and the double group was the combined treatment group,with 42 cases in each group.Among them,the patients in the terbutaline group were treated with nebulized inhalation of terbutaline,and the patients in the combination group were treated with montelukast sodium combined with terbutaline inhalation,followed by observation of the treatment of the two groups.Percentage of maximal expiratory flow before and after treatment in children before and after treatment as a percentage of normal predicted value(PEF%),1 s forced expiratory volume(FEV1),and 1 s forced expiratory volume occupancy vital capacity percentage(FEV1/FVC)and other indicators.Results PEF%,FEV1,FEV1/FVC and therapeutic effects were better in the combination group and the terbutaline group,but the in-dicators in the combination group were better[(96.73±4.53)%,(2.99±0.56)L,(71.89±3.88)%,97.6%VS(91.67±4.29)%,(2.71±0.66)L,(67.50±3.45)%,73.8%],and the difference was statistically significant(t=5.256,2.096,5.480,χ~2=9.722,P<0.05),the test t values were:.Conclusion The efficacy of montelukast sodium combined with terbutaline inhalation in the treatment of children with cough variant asthma with Mycoplasma pneumoniae infection is significant,can effectively improve the treatment effect,it is worth further promotion and use.