还原型谷胱甘肽钠治疗小儿急性感染性疾病致肝功能损害临床效果分析

Clinical Effect Analysis of Reduced Glutathione Sodium on Hepatic Dysfunction Caused by Acute Infectious Diseases in Children

目的分析评价还原型谷胱甘肽钠治疗小儿急性感染性疾病致肝功能损害临床效果。方法该次采取随机数字表法,将该院于2017年2月—2018年2月收治的84例小儿急性感染性疾病致肝功能损害患儿分成两组,每组平均为42例;其中,对照组患儿采取常规维生素C及甘草酸二铵治疗,观察组患儿采取还原型谷胱甘肽钠治疗,进一步对两组临床治疗效果进行对比评价。结果观察组、对照组治疗总有效率分别为95.24%、73.81%,观察组显著要比对照组高(χ~2=10.238,P<0.05)。治疗后,观察组ALT、AST、γ-GT水平分别为(60.32±35.87)U/L、(61.79±27.84)U/L、(51.86±20.32)U/L,明显低于对照组的(94.58±36.12)U/L、(93.89±40.25)U/L、(65.98±20.34)U/L,观察组改善效果均显著要比对照组更优(t=8.283、8.283、5.124,P<0.05)。观察组并发症总发生率(7.14%)明显低于对照组(23.81%),差异有统计学意义(χ~2=11.356,P<0.05)。结论在临床中,针对小儿急性感染性疾病致肝功能损害患儿,采取还原型谷胱甘肽钠治疗具备显著的疗效,能够促进患儿肝功能水平的改善,并使并发症的发生得到有效控制,同时提高患儿家属对治疗工作的满意程度;因此,值得采纳及应用。

Objective To evaluate the clinical effect of reduced glutathione sodium on hepatic dysfunction caused by acute infectious dis-eases in children.Methods This randomized digital table method was used to divide 84 children with acute liver infection caused by acute infectious diseases in the hospital from February 2017 to February 2018 into two groups,with an average of 42 cases in each group.The children in the control group were treated with conventional vitamin C and diammonium glycyrrhizinate.The children in the observation group were treated with reduced glutathione sodium,and the clinical effects of the two groups were further evaluated.Results The total effective rate of the observation group and the control group were 95.24%and 73.81%,respectively.The observation group was significantly higher than the control group(χ~2=10.238,P<0.05).After treatment,the levels of ALT,AST andγ-GT in the observation group were(60.32±35.87)U/L,(61.79±27.84)U/L,(51.86±20.32)U/L,which were significantly lower than those of the control group,(94.58±36.12)U/L,(93.89±40.25)U/L,(65.98±20.34)U/L.Both were significantly better than the control group(t=8.283,8.283,5.124,P<0.05).The total incidence of complications in the observation group(7.14%)was significantly lower than that in the control group(23.81%),which was statistically significant(χ~2=11.356,P<0.05).Conclusion In the clinical practice,children with liver dysfunction caused by acute infectious diseases in children have significant curative effect on reducing glutathione sodium,which can improve the liver function of children and make the complications effective control,while improving the satisfaction of the family members of the treatment work;therefore,it is worthy of adoption and application.