肝素在重度妊高征治疗中的应用效果评价

Evaluation of the Application Effect of Heparin in the Treatment of Severe Pregnancy Induced Hypertension

目的讨论肝素在重度妊高征治疗中的应用效果。方法将该院2018年6月—2019年6月期间收治的84例妊高证患者随机分为对照组(接受传统治疗)与研究组(对照组基础上加用肝素进行治疗)。观察比较两组的血压、尿蛋白、日尿量及母婴不良症状发生率。结果治疗后研究组患者收缩压(122.69±5.54)mmHg及舒张压(70.65±3.34)mmHg均明显低于对照组(t=10.980、13.792,P<0.05)。治疗后研究组患者尿蛋白(15.62±6.34)g/d及日尿量(2872.84±650.36)mL明显均高于对照组(t=7.296、9.374,P<0.05)。研究组出现宫缩乏力的4.76%、产后出血的2.38%、胎儿宫内窘迫的4.76%及新生儿窒息的2.38%均分别明显低于对照组(χ~2=6.222、8.473、8.571、8.473,P<0.05)。结论重度妊高征病症治疗期间给予患者小剂量肝素药物可有效的改善血压水平,提高其尿蛋白及日尿量,降低母婴不良妊娠症状发生率,值得推广。

Objective To discuss the application effect of heparin in the treatment of severe pregnancy induced hypertension.Methods Eighty-four patients with pregnancy-induced hypertension admitted to the hospital from June 2018 to June 2019 were randomly divid-ed into the control group(conventional treatment)and the study group(the control group was treated with heparin).To analysis blood pressure,urine protein,daily urine output and the incidence of maternal and child symptoms between the two groups.Results After treatment,the systolic blood pressure(122.69±5.54)mmHg and the diastolic blood pressure(70.65±3.34)mmHg were significantly lower than the control group(t=10.980,13.792,P<0.05).After treatment,the urinary protein(15.62±6.34)g/d and the daily urine output(2872.84±650.36)mL were significantly higher than the control group(t=7.296,9.374,P<0.05).The study group had 4.76%of uterine weakness,2.38%of postpartum hemorrhage,4.76%of intrauterine distress and 2.38%of neonatal asphyxia,respectively,which were significantly lower than the control group(χ~2=6.222,8.473,8.571,8.473,P<0.05).Conclusion The administration of low-dose heparin drugs during the treatment of severe pregnancy-induced hypertension can effectively improve blood pressure,increase urine protein and daily urine output,and reduce the incidence of maternal and child adverse pregnancy symptoms.It is worth promoting.