干姜小柴胡汤治疗新型冠状病毒奥密克戎变异株感染轻型患者的临床观察

Clinical observation on Ganjiang Xiaochaihu Decoction in treating patients with mild infection of COVID-19 Omicron variant

目的观察干姜小柴胡汤治疗新型冠状病毒奥密克戎变异株感染轻型患者的临床疗效。方法将145例新型冠状病毒奥密克戎变异株感染轻型患者随机分为治疗组(97例)和对照组(48例),对照组予基础治疗,治疗组在对照组治疗基础上加用干姜小柴胡汤。治疗5 d后观察临床疗效,比较两组中医证候积分、抑郁自评量表(SDS)评分、焦虑自评量表(SAS)评分及核酸转阴时间。结果(1)试验过程中,对照组脱落1例,最终完成试验者治疗组97例、对照组47例。(2)治疗组总有效率为99.0%,对照组总有效率为78.7%,治疗组临床疗效优于对照组(P<0.05)。(3)治疗5 d后与治疗前组内比较,两组中医证候各分项积分及总积分均减少,差异有统计学意义(P<0.05);组间治疗5 d后比较,治疗组咽部不适、鼻塞流涕、食欲不振、心情烦躁、心悸积分及中医证候总积分少于对照组,差异有统计学意义(P<0.05)。(4)治疗5 d后与治疗前组内比较,两组SDS、SAS评分降低,差异有统计学意义(P<0.05);组间治疗5 d后比较,治疗组SDS、SAS评分低于对照组,差异有统计学意义(P<0.05)。(5)两组核酸转阴时间比较,差异无统计学意义(P>0.05)。结论干姜小柴胡汤治疗新型冠状病毒奥密克戎变异株感染轻型患者疗效满意,可有效改善患者的中医证候,缓解抑郁、焦虑情绪,具有“病郁同治”的功效。

Objective To observe the clinical effect of Ganjiang Xiaochaihu Decoction on patients with mild infection of COVID-19 Omicron variant.Methods One hundred and forty-five patients with mild infection of COVID-19 Omicron variant were randomly divided into a treatment group(n=97)and a control group(n=48).The control group was given basic routine treatment,while the treatment group was administered with Ganjiang Xiaochaihu Decoction and the basic routine treatment.After 5 days of treatment,the clinical effect was observed,and TCM syndrome scores,selfrating depression scale(SDS)scores,self-rating anxiety scale(SAS)scores and nucleic acid conversion time(NCT)were compared between the two groups.Results(1)During the trial,1 case in the control group dropped out,and finally 97 cases in the treatment group and 47 cases in the control group completed the trial.(2)The total effective rate of the treatment group was 99.0%,and that of the control group was 78.7%.The treatment group showed a better clinical effect compared with the control group(P<0.05).(3)After 5 days of treatment,the TCM syndrome sub-item scores and total scores in both groups decreased,and the differences were statistically significant(P<0.05);After 5 days of treatment,the sub-item scores of pharyngeal discomfort,nasal obstruction and runny nose,loss of appetite,irritability,palpitation and the TCM syndrome total scores in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).(4)The scores of SDS and SAS in the two groups decreased after 5 days of treatment compared with those before treatment,and the differences were statistically significant(P<0.05);After 5 days of treatment,the scores of SDS and SAS in the treatment group were lower than those in the control group,and the differences were statistically significant(P<0.05).(5)There was no statistically significant difference between the two groups in terms of nucleic acid conversion time(P>0.05).Conclusion Ganjiang Xiaochaihu Decoction has achieved a satisfactory result in treating patients with mild infection of COVID-19 Omicron variant because it can effectively improve the patients’TCM syndromes,relieve depression and anxiety,and has the effect of“simultaneous treatment of infection and depression”.