核心指标集方法学研究进展

Advances in core outcome set methodology

为应对临床研究评价指标存在的不规范、不一致、不重要等问题,方法学专家提出了核心指标集(COS)的概念。有效性试验核心结局指标(COMET)工作组的成立,促进了COS的国际化推广和应用。从COS的概念及作用、COS研究平台、COS研制方法、中医药临床研究核心指标集(COS-TCM)等四个方面进行阐述,为核心指标集研究提供参考。

To deal with the nonstandard,inconsistent and unimportant clinical research evaluation indicators,methodologists put forward the concept of core outcome set(COS).The establishment of core outcome measures in effectiveness trials(COMET)working group has facilitated the international promotion and application of COS.This paper expounds the concept and function of COS,COS research platforms,COS development methods,and the core outcome set of traditional Chinese medicine(COS-TCM)for clinical trials,thereby providing references for the research of core outcome set.