吴门清热化浊方联合外敷金黄膏治疗急性痛风性关节炎的临床研究

Clinical study on treatment of acute gouty arthritis with Wumen Qingre Huazhuo Formula combined with external application of golden plaster

目的观察吴门清热化浊方联合外敷金黄膏治疗急性痛风性关节炎的临床疗效及安全性。方法将62例急性痛风性关节炎患者随机分为治疗组和对照组,每组31例。治疗组予以吴门清热化浊方及外敷金黄膏治疗,对照组口服依托考昔片及外用七叶皂苷钠凝胶治疗,两组均连续治疗1周。观察比较两组患肢疼痛VAS评分、肿胀程度、皮肤温度、白细胞、C反应蛋白及血尿酸变化情况,以及药物的不良反应发生率。结果与对照组比较,治疗组患者治疗6 h VAS评分无显著性变化(P>0.05),治疗1 d、治疗7 d后VAS评分显著降低(P<0.05);与对照组比较,治疗组患者治疗后患肢肿胀评分、皮温评分、C反应蛋白水平显著降低(P<0.05),白细胞、血尿酸水平为无显著性变化(P>0.05);治疗组不良反应发生率为9.68%,对照组为12.90%,组间差异无统计学意义(P>0.05)。结论吴门清热化浊方联合外敷金黄膏能较好地缓解痛风性关节炎急性期症状、改善关节功能、减轻炎症反应,且不增加药物不良反应发生率。

Objective To observe the clinical efficacy and safety of Wumen Qingre Huazhuo Formula combined with external application of golden plaster in the treatment of acute gouty arthritis.Methods A total of 62 patients with acute gouty arthritis were randomly divided into treatment group and control group,31 cases in each group.The patients in the treatment group were treated with Wumen Qingre Huazhuo Decoction and external application of golden plaster,while the patients in the control group were treated with oral etoricoxib and external application of Sodium aescinate gel.After persistent treatment for 1 week,the pain VAS score,degree of swelling,temperature of skin,leukocyte,C-reactive protein and serum uric acid,as well as the incidence of adverse drug reactions were compared between the two groups.Results Compared with the control group,the VAS score of the treatment group had no significant change at 6 h after treatment(P>0.05),but the VAS scores decreased significantly at 1 day and 7 days after treatment(P<0.05).Compared with the control group,swelling score,skin temperature score and C-reactive protein levels of the affected limbs in the treatment group decreased significantly at 7 days after treatment(P<0.05),while the levels of leukocyte and serum uric acid had no significant change(P>0.05).The incidence of adverse drug reactions was 9.68%in the treatment group and 12.90%in the control group,the difference was not statistically significant(P>0.05).Conclusion Wumen Qingre Huazhuo Formula combined with external application of golden plaster can better relieve the acute symptoms of gouty arthritis,improve joint function,reduce inflammation,and do not increase the incidence of adverse drug reactions in the treatment of acute gouty arthritis.