黄芪注射液穴位注射治疗化疗后白细胞减少症的临床研究

Clinical study on acupoint injection of astragalus injection in the treatment of leukopenia after chemotherapy

目的观察黄芪注射液足三里穴位注射治疗恶性肿瘤化疗后白细胞减少症的临床疗效。方法将70例化疗后白细胞减少症患者随机分为治疗组35例和对照组35例。治疗组给予足三里穴位注射黄芪注射液1 mL/次,1次/d,同时口服利血生、鲨肝醇20 mg/次,3次/d;对照组给予口服利血生、鲨肝醇20 mg/次,3次/d。两组分别于治疗前及治疗后5 d、10 d、14 d检查血常规、肝肾功能。比较两组治疗前后白细胞计数及Karnorsky评分,通过比较两组治疗前后肝肾功能指标的情况评价其安全性。结果①治疗组脱落2例,对照组脱落3例,最终完成试验者65例,其中治疗组33例、对照组32例。②治疗组和对照组的总有效率分别为84.8%、65.6%;治疗组临床疗效优于对照组(P<0.05)。③治疗5 d、治疗10 d组间比较,白细胞计数差异有统计学意义(P<0.05);治疗14 d组间比较,两组白细胞计数、血红蛋白量及血小板计数差异无统计学意义(P>0.05)。④治疗14 d后与治疗前组内比较,两组卡氏评分差异无统计学意义(P>0.05);治疗14 d后组间比较,卡氏评分差异无统计学意义(P>0.05)。⑤两组肝肾功能均未见明显异常,未见明显不良反应。结论与单纯口服利血生、鲨肝醇片相比,黄芪注射液穴位注射能更好地稳定化疗患者的白细胞水平,且无明显不良反应。

Objective To observe the clinical efficacy of astragalus injection with acupoint injection at Zusanli in the treatment of leukopenia after chemotherapy for malignant tumors. Methods Seventy cases of leukopenia after chemotherapy were radomly divided into the treatment group(35 cases) and control group(35 cases). The treatment group was treated with astragalus injection by acupoint injection at Zusanli, 1 mL every time, once a day, meanwhile orally treated with leucogen and batyl alcohol, 20 mg every time, 3 times a day. The control group was orally treated with leucogen and batyl alcohol, 20 mg every time, 3 times a day. The blood routine test and liver and kidney function detection were performed before treatment and on the 5 th, 10 th and 14 th day after treatment. The white blood cell count and Karnorsky score were compared before and after treatment between the two groups, and the liver and kidney function indexes were compared before and after treatment between the two groups to evaluate the safety. Results ①Two cases in the treatment group and three cases in the control group dropped out. Finally 65 cases completed the trial, among 33 cases in the treatment group and 32 cases in the control group. ②The total effective rates of the treatment group and the control group were 84.8% and 65.6% respectively, and the clinical efficacy of the treatment group was better than that of the control group(P<0.05). ③On the 5 th and 10 th day after treatment, there was statistically significant difference in white blood cell count between the two groups(P<0.05). On the 14 th day after treatment, there were no statistically significant differences in white blood cell count, hemoglobin count and platelet count between the two groups(P>0.05). ④Compared with treatment before, there was no statistically significant difference in Karnorsky score in both groups after treatment for 14 days(P>0.05). After treatment for 14 days, there was no statistically significant difference in Karnorsky score between the two groups(P>0.05). ⑤There were no obvious abnormality of liver and kidney function indexes and no obvious adverse reactions in the two groups. Conclusion Compared with leucogen and batyl alcohol alone,astragalus injection with acupoint injection can better stabilize the leukocyte level of chemotherapy patients,and shows no obvious adverse reactions.