肝积方治疗TACE术后中晚期原发性肝癌的临床研究

Clinical study on Ganji Formula in treating advanced primary liver cancer after TACE

目的观察肝积方治疗肝动脉栓塞化疗术(TACE)术后中晚期原发性肝癌的临床疗效。方法将120例TACE术后中晚期原发性肝癌患者随机分为治疗组和对照组,每组60例。对照组予基础对症治疗,治疗组在基础对症治疗的基础上加予肝积方治疗。两组疗程均为6个月、随访6个月,观察两组病死率、实体瘤疗效,比较肝功能、AFP、中医证候积分的变化情况。结果①在治疗3个月、治疗6个月、随访3个月时,两组病死率差异均无统计学意义(P>0.05);在随访6个月时,两组病死率差异有统计学意义(P<0.05)。②组间实体瘤疗效比较,差异无统计学意义(P>0.05)。③治疗前后组内比较,两组TBil、ALT、AST、AFP水平差异无统计学意义(P>0.05),对照组ALP、γ-GT、ALB水平差异有统计学差异(P<0.05)。组间治疗后比较,各指标差异均无统计学意义(P>0.05)。④治疗前后组内比较,中医证候积分有统计学差异(P<0.05);组间治疗前后差值比较,治疗组大于对照组(P<0.05)。结论肝积方治疗TACE术后中晚期原发性肝癌患者,可降低病死率,改善患者临床脘闷腹胀、纳差、乏力、恶心呕吐等不适症状,维持肝功能的相对稳定,延缓病情进展;在实体瘤疗效方面,肝积方与基础治疗疗效相似。

Objective To observe the clinical efficacy of Ganji Formula in treating advanced primary liver cancer after transcatheter arterial chemoembolization(TACE).Methods One hundred and twenty patients with advanced primary liver cancer after TACE were randomly divided into the treatment group and control group,60 cases in each group.The control group was treated with basic symptomatic treatment,and the treatment group was treated with Ganji Formula on the basis of basic symptomatic treatment.The treatment course was 6 months,and both groups were followed-up for 6 months.The mortality and efficacy on solid tumor were observed in the two groups,and the changes of liver function,AFP and Chinese medical syndrome score were compared.Results①Three months after treatment,6 months after treatment and 3 months after follow-up,there was no statistically significant difference in mortality between the two groups(P>0.05).Six months after follow-up,there was statistically significant difference in mortality between the two groups(P<0.05).②There was no statistically significant difference in efficacy on solid tumor between the two groups(P>0.05).③In both groups,there were no statistically significant differences in levels of TBil,ALT,AST and AFP between treatment before and after(P>0.05).In the control group,there were statistically significant differences in levels of ALP,γ-GT and ALB between treatment before and after(P<0.05).After treatment,there were no statistically significant differences in all indicators between the two groups(P>0.05).④In both groups,there was statistically significant difference in Chinese medical syndrome score between treatment before and after(P<0.05).After treatment,the D-value of Chinese medical syndrome score in the treatment group was greater than that in the control group(P<0.05).Conclusion Ganji Formula can reduce the mortality of patients with advanced primary liver cancer after TACE,improve the clinical symptoms such as abdominal distention,poor appetite,fatigue,nausea and vomiting,maintain the relative stability of liver function,and delay the progress of the disease.In the treatment of solid tumor,the efficacy of Ganji Formula is similar to the basic treatment.