五禽戏联合钙剂治疗原发性骨质疏松症的临床研究

Clinical study on five animal exercises combined with calcium in the treatment of primary osteoporosis

目的观察五禽戏联合钙剂治疗原发性骨质疏松症的临床疗效。方法将100例原发性骨质疏松症患者随机分为治疗组和对照组,每组50例。对照组口服碳酸钙D3片(钙尔奇)治疗,治疗组在对照组基础上联合五禽戏锻炼,两组疗程均为6个月。观察两组治疗前后血清钙(Ca)、磷(P)及骨钙素(BGP)、Ⅰ型前胶原氨基端肽(P1NP)、腰椎1-4(L1-L4)及股骨颈骨密度(BMD)、腰背痛评分、肢体活动状况(SPPB)评分变化情况。结果①治疗前后组内比较,治疗组血清Ca、P水平明显升高(P<0.05),BGP、P1NP水平明显下降(P<0.05),对照组Ca、P、BGP、P1NP无明显变化(P>0.05);组间治疗后比较,治疗组BGP、P1NP水平明显低于对照组(P<0.05)。②治疗前后组内比较,治疗组L1-L4、股骨颈的BMD明显升高(P<0.05),对照组无明显变化(P>0.05);组间治疗后比较,治疗组的L1-L4、股骨颈的BMD明显高于对照组(P<0.05)。③治疗前后组内比较,治疗组腰背痛评分明显降低(P<0.05),SPPB评分明显升高(P<0.05),对照组腰背痛评分、SPPB评分均无明显变化(P>0.05);组间治疗后比较,治疗组腰背痛评分明显低于对照组(P<0.05),SPPB评分明显高于对照组(P<0.05)。结论五禽戏可以显著改善骨质疏松症患者骨代谢生化指标,提高骨密度,改善疼痛及肢体活动状况,对骨质疏松症有良好的治疗作用。

Objective To observe the effect of five animal exercises combined with calcium in the treatment of primary osteoporosis metabolism in osteoporosis patients.Methods One hundred patients with osteoporosis were randomly divided into treatment group(n=50)and control group(n=50).The control group was given Caltrate calcium treatment while the treatment group was treated with five animal exercises combined with calcium.The treatment course was 6 months.Serum calcium(Ca),phosphorus(P),Bone Gla-protein(BGP),Procollagen I N-Terminal Propeptide(P1 NP)levels were measured before and after treatment;changes in the bone mineral density(BMD)of lumbar spine 1-4(L1-L4)and femoral neck were recorded and the low back pain score and SPPB were recorded and analyzed before and after treatment.Results①Serum Ca and P levels in the treatment group increased significantly(P<0.05),while BGP and P1 NP levels decreased significantly(P<0.05).There was no statistically significant difference in Ca,P,BGP and P1 NP levels in the control group(P>0.05).After treatment,BGP and P1 NP levels in the treatment group were significantly lower than those in the control group(P<0.05).②Intramural comparison before and after treatment showed that BMD levels of lumbar 1-4(L1-L4)and femoral neck in the treatment group increased significantly while BMD levels of lumbar 1-4(L1-L4)and femoral neck in the control group were not statistically significant(P>0.05).After treatment,BMD levels of lumbar 1-4(L1-L4)and femoral neck in the treatment group were significantly higher than those in the control group(P<0.05).③Intra-group comparison before and after treatment showed that the low back pain score in the treatment group reduced significantly(P<0.05),while the SPPB score increased significantly(P<0.05).There was no statistically significant difference of the low back pain score and SPPB score in the control group(P>0.05)before and after treatment.After treatment,the scores of low back pain in the treatment group were significantly lower than those in the control group(P<0.05),and the SPPB scores were significantly higher than those in the control group(P<0.05).Conclusion Five animal exercises can exert a good therapeutic effect on osteoporosis by significantly improving the biochemical index of bone metabolism,increasing BMD,facilitating physical movement and reducing pain in patients with osteoporosis.