加味四君子汤治疗肺脾气虚型常年性变应性鼻炎的临床研究

Clinical study of Modified Sijunzi Decoction in treating perennial allergic rhinitis with syndrome of deficiency of lung and spleen qi

目的:观察加味四君子汤治疗肺脾气虚型常年性变应性鼻炎的临床疗效。方法:纳入118例肺脾气虚型常年性变应性鼻炎患者作为研究对象,随机分为治疗组与对照组,每组59例。治疗4周后比较两组临床疗效、VAS评分、四分法评分、鼻内镜评分以及中医证候评分。结果:①治疗过程中两组各脱落2例,所有病例未见不良反应发生。②治疗4周后,治疗组与对照组总有效率分别为91.23%、75.44%,差异有统计学意义(P<0.05)。③治疗组的VAS评分、四分法评分、下鼻甲大小、鼻黏膜颜色评分低于对照组,在清涕量多、气短乏力、大便溏薄、受冷易发、鼻塞、流涕症状、下鼻甲大小评分改善上两者差别有统计学意义(P<0.05)。结论:加味四君子汤联合盐酸西替利嗪片在改善鼻塞、流涕、下鼻甲大小、清涕量多、气短乏力、大便溏薄、受冷易发方面优于单用盐酸西替利嗪。

Objective:To observe the clinical efficacy of Modified Sijunzi Decoction in treating perennial allergic rhinitis with syndrome of deficiency of lung and spleen qi.Methods:One hundred and eighteen cases of perennial allergic rhinitis with syndrome of deficiency of lung and spleen qi were included as subjects,and were randomly divided into the treatment group and control group,59 cases in each group.The treatment course was 4 weeks in both groups.The clinical efficacy,VAS score,quadrant score,nasal endoscopy score and TCM syndrome score were compared between the two groups.Results:①During the treatment,2 cases fell off in each group,and no adverse reactions were found in all cases.②After treatment for 4 weeks,the total effective rates of the treatment group and the control group were 91.23%and 75.44%respectively,with statistically significant difference(P<0.05).③The VAS score,quartile score,size of inferior nasal concha and nasal mucosa color score in the treatment group were lower than those in the control group.There were statistically significant differences between the two groups in the improvement of large amount of clear runny nose,shortness of breath,weakness,loose stool,cold prone,nasal congestion,runny nose symptoms and size of inferior nasal concha(P<0.05).Conclusion:Compared with cetirizine hydrochloride alone,Modified Sijunzi Decoction combined with cetirizine hydrochloride shows better improvements on nasal congestion,runny nose,size of inferior nasal concha,large amount of runny nose,shortness of breath and fatigue,loose stool and cold prone.