以三尖杉酯碱为主的HOP和HOP-HOCP方案治疗白细胞不增多型急性早幼粒细胞白血病

HOP AND HOP-HOGP PROTOCOLS IN THE TREATMENT OF ALEUKEMIG AGUTE PROMYELOCYTIG LEUKEMIA

以三尖杉酯碱(H,1~2mg),每日静脉连续滴注为主的各种方案,治疗外周血白细胞<3×10~9/L的白细胞不增多型急性早幼粒细胞白血病(急早幼)32例,有23例完全缓解(71.8%)。本方案对血细胞的抑制轻而短暂,虽未同时应用肝素,在疗程中亦未见因白细胞急骤下降而出现弥漫性血管内凝血。

Thirty-two aleukemic acute promyelocytic leukemia patients with blood WBC<3×10~9/L were treated by various combined protocols which included small dose of harringtonine(1-2 ng every day)given by continous intravenous drip.Twenty-three cases obtained complete remission(71.8%).All these protocols caused mild and transient depression of blood cells.Although heparin was not simultaneously used,there was no evidence of disseminated intravenous coagulation developed during the treatment due to sudden decrease of white blood cell count.