摘要
本文报道尼可刹米治疗慢性阻塞性肺病(下称慢阻肺)呼吸衰竭的肺功能变化,并通过动物实验探讨治疗机制。临床观察和动物实验结果显示,慢阻肺伴CO潴留时,尼可刹米仍可兴奋呼吸中枢、提高通气量。但由于慢阻肺呼吸运动机械阻力增加、通气量的提高,将促使机体代谢率上升,可抵消兴奋呼吸所起的缓解缺氧和CO潴留的积极作用,甚至适得其反。因此,使用尼可刹米时,应同时采取措施减少呼吸机械阻力,以发挥药物的积极作用。
Nikethamide therapy in 15 patients with respiratory failure of chronic obstructive pulmonary disease(COPD)and 8 dogs with increased airway and elastic resistance was clinically and experimentally studied.The lung functions after treatment showed various degrees of improvement.Nikethamide still had the effect of stimulation of respiratory center and enhancement of ventilation even though chronic pulmonary obstruction with COretention was present.The enhanced ventilation would induce the uprising of.metabolic rate,thus the improvement in hypoxia and COretention might be diminished However,it is emphasized that measures to reduce elastic and airway resistance should be taken when nikethamide is given.
出处
《上海医学》
CAS
1988年第7期373-378,共6页
Shanghai Medical Journal
