99m锝-微球灌注肺扫描剂的动物实验和临床初步应用

THE ANIMAL EXPERIMENTS AND CLINICAL APPLICATIONS OF 99mTc-HAM LUNG PERFUSION SCANNING AGENT

本文介绍一种新的肺灌注扫描剂——99m锝-人血清白蛋白微球。动物实验发现其90%分布在肺部。兔、狗肺扫描结果,两肺界限分明,图影清楚。临床检查胸部疾病65例,图影清晰,病变部位易于识别。该扫描剂在肺部潴留时间较长,有充足的时间做多体位扫描。m锝半衰期较短,受检者遭受辐射剂量小。其能量中等,适用于闪烁扫描仪,尤其是γ照相机。

99Tc-HAM is a new lung scanning agent.Animal experiments in dogs and rabbits revealed that 90%of intravenously injected radioactive particles were trapped in the lungs.Sixty-five cases with pulmonary diseases were studied clinically.There were no side effects observed.The scanning images of both patients and animals were clear,they reflected the anatomic configuration of the lungs and the changes in pulmonary blood flow.