三尖杉类酯碱化疗方案治疗急性非淋巴细胞性白血病的临床疗效分析

CLINICAL STUDY OF CEPHALOTAXIN ESTER IN THE TREATMENT OF ACUTE NON-LYMPHOID LEUKEMIA

本文比较了单用H、HOC加减及HOAP方案治疗急性非淋巴细胞性白血病140例的疗效。HOAP及HOC的疗效(53.4%、56.00%)显著高于单用H组(25%),P<0.05,而HOAP与HOC相比,P>0.05。但HOAP比HOC更易引起严重并发症。建议对不增生型白血病以单用三尖杉为宜,对白细胞、血小板比较低且临床上有严重感染及出血的患者,以HOC加减为宜,对白细胞明显增高者,以HOAP为宜。

Therapeutic effects of H(Harringtonine or Homoharringtonine), HOC and HOAP were studied and compared in 140 patients with acute non-lymphoid leukemia. Complete remission achieved by H, HOC and HOAP was 25%, 53% and 56.0% respectively. The HOC and HOAP groups had greater hematopoietic depression side effect than H group. Although there was no difference in the hematopoietic depression between HOC and HOAP groups, bleeding and severe infection were more common in HOAP group. We suggest the, selective use of these different protocols in different conditions. HOAP is preferable in severe cases with significantly elevated WBC, and HOC in cases with only moderately elevated WBC or with complication of bleeding or infection. For those who are severely leucopenic, the use of H is preferable.