Ⅷ因子相关抗原测定在原发性肾小球肾炎中的临床意义

CLINICAL SIONIFICANCE OF PLASMA Ⅷ R: Ag IN PRIMARY GLOMERULONEPHRITIS

作者对125例住院和门诊各型原发性肾小球肾炎病人,进行血浆VIII R∶Ag的测定。检查发现,除肾病型恢复期外,其它各型原发性小球性肾炎的VIII R∶Ag都高于正常对照。在肾病综合征时,VIII R∶Ag值与尿蛋白量呈正相关,与血浆白蛋白呈负相关(包括尿毒症、氮质血症)。血浆纤维蛋白升高者,VIII R∶Ag也显著高于正常。结论认为,VIII R∶Ag值的升高,可反映血管内膜的损伤,其升高幅度随肾功能恶化程度而相应增大,有助于估计预后.对VIII R∶Ag升高的机理进行了讨论。

Plasma levels ofⅧR:Ag in 125 patients with primary glomerulonephritis of various etiology,including 30 patients with uremia,12 azotemia,59 nephrotic syndrome and 24 general type glomerulonephritis,were determined.The results showed that the plasma levels ofⅧR:Ag were increased in all except the nephrotie patients with remission,as compared with the control The plasma level ofⅧR:Ag positively correlated with the magnitude of proteinuria in patients with nephrotic syndrome,whereas negative correlation was observed between plasma level ofⅧR:Ag and plasma albumin in nephrotie patients with normal or impaired renal function.The plasma level ofⅧR:Ag was significantly increased in patients with increased plasma fibrin.The extent of increase in plasma level ofⅧR:Ag was related with the severity of impaired renal function.It is suggested that increased plasma level ofⅧR:Ag might be related to the endothelial damage and have a prognostic value in these patients.The mechanism of increased plasma level ofⅧR:Ag is discussed.