血清病样痢特灵药疹40例分析

FURAXONE INDUCED SERUM SICKNESS-LIKE REACTION

本文报告血清病样痢特灵药疹40例,有34例作了溶血性补体总量(CH)测定,均属正常范围;对其中18例在症状消退后进行了复查,发现恢复期测值比发作期有显著升高(P<0.05)。本组有14例(35%),其荨麻疹及皮肤划痕征的症状迁延1月以上,病程最长者达半年余。

Forty patients with drug eruptions induced by furaxone are reported.The averagelatent period was 9.7 days.Clinical features consisted of urticarial lesions,fever,arthralgia and enlargement of lymphnodes.3 patients also had renal involvement mani-fested by proteinuria and hematuria.ESR and γ-globulin level were elevated occasion-ally,and in some patients anti-complementary activity test was positive and serumcomplement levels raised after the symptoms had subsided.The latent period,clinicalmanifestations and laboratory findings indicated this type of drug eruption might be aserum sickness like reaction,a type Ⅲ hypersentivity reaction induced by the antigen-antibody complex.