原发性骨髓纤维化50例分析

PRIMARY MYELOFIBROSIS:ANALYSIS OF 50 CASES

本文总结1955~1980年的原发性骨髓纤维化共50例,其中48例经骨髓活检证实,另2例经脾脏病理检查证实有髓外造血而确诊.本组病例男性39例,女性11例。常见症状为乏力、头昏。脾脏肿大为最突出的体征,有5例在诊断本病前,已做了脾脏切除术。周围血有11例出现泪滴状红细胞,36例出现幼红细胞,有37例出现幼稚粒细胞。骨髓病理检查以骨髓萎缩与纤维化型最为常见。怍者对诊断、鉴别诊断、中西医结合治疗,以及本病与骨髓增殖性疾病间的关系作了讨论。

From 1955 to 1980,50 cases of primary myelofibrosis were treated in 13 hospitalsof Shanghai,with 48 cases confirmed by bone marrow biopsy and 2 by splenic evidenceof extramedullary hemopoiesis.Among the 50 cases,39 were male and 11 female,themedian age being 48.5.The common symptoms were fatigue(70%)and dizziness(58%).Splenomegaly was the most prominent sign(47.7%).Peripheral blood smears revealedtear-drop shaped erythrocytes in 11 cases,nucleated erythrocytes in 36 and younggranulocytes in 37.Myeloid atrophy and fibrosis were the common histological patternsseen in bone marrow sections.The diagnosis,treatment by traditional and westernmedicine and the interrelationship between primary myclofibrosis and myeloproliferativedisorder were discussed.