131Ⅰ标记争光霉素沪Ⅱ号的钴螯合物应用于肺癌阳性扫描的初步观察

PRELIMINARY REPORT ON THE RADIOISOTOPIC SCANNING AGENT Co-131Ⅰ BLEOMYCIN (Ⅱ)FOR DETECTING LUNG CANCER

本文根据Co-131I-沪Ⅱ争光霉素在带瘤小鼠中所显示的亲肿瘤特性,对22例不同病理类型肺癌和15例非癌的其他肺部疾患进行了同位素扫描研究,结果发现22例肺癌中有21例(95.4%)见肿瘤部位有放射性积聚,15例非癌性肺部疾患中除3例显示不同程度的放射性积聚外,余11例皆阴性,提示Co-131I-沪Ⅱ争光霉素有可能作为肺癌诊断的一种阳性扫描剂。

Co-131I-BL(Ⅱ)was applied clinically by the authors in scintiscan of lung cancer since it had been proved to be oncophilic in tumor bearing mice.22 cases of lung cancer,including squamous cell carcinoma,adenocarcinoma and undifferentiated carcinoma,were scanned 24 hrs after injection of 2 mCi of Co-131I-BL(Ⅱ),with 21(95.4%)showing a positive image of the malignant lesion.15 cases of non-cancerous pulmonary diseases served as control,with 2 pulmonary tuberculosis and 1 bronchiectasis cases showing false positive images.These preliminary results suggest that the use of Co-131I-BL(Ⅱ)as a radiolabled positive imaging agent for detection of lung cancer may be promising.