免疫疗法治疗流行性出血热

IMMUNO SUPPRESSIVE THERAPY OF EPIDEMIC HEMORRHAGIC FEVER

我们应用免疫抑制药物环磷酰胺治疗流行性出血热(60例),获得较好的效果。为了进一步提高疗效,我们又以环磷酰胺加党参、黄芪(45例)和环磷酰胺加干扰素诱导剂聚肌胞(Poly I:C)(21例)治疗流行性出血热。并对部分患者的免疫功能和临床表现进行了观察和疗效比较。治疗后的三组患者其免疫功能即趋恢复,同时临床症状也显著改善。其中环磷酰胺加党参、黄芪和环磷酰胺加Poly I:C组的疗效较单用环磷酰胺者为优,且淋转率的回升也较明显;环磷酰胺加Poly I:C的退热效果尤较前两组为佳。126例中124例治愈,2例死亡,病纯率1.58%。本文并对治疗的作用进行了讨论。

126 cases of epidemic hemorrhagic fever were treated with the immuno-suppressiveagents in 1973—1978.Among them,60 cases were treated with cyclophosphamide alone(first group),45 treated with cyclophosphamide plus radix codonopsis pilosulae andradix astragali(second group)and 21 treated with cyclophosphamide plus interferoninducer Poly I:C(third group).The immunologic status as well as clinicalpictures of these patients were observed before and after treatment.The immunologicaldeterminations disclosed:(1)an increase of humoral immunity(elevated IgG,IgM andIgA levels),(2)a significant decrease of complement levels(CHand C)and(3)aninhibition of cellular immunity(lymphoblast transformation rate).It was shown thatthe immunity functions were restored to normal and clinical symptoms were also muchimproved after treatment.In most of the patients(90.7%),the hypotensive and/orthe oliguria phase did not appear in the course of the disease.The mortality rate hadbeen reduced from 15.0%to 1.6%.The therapeutic results of the second and thirdgroups were found to be better than those of the first group,with the third groupbeing the best.