胃双重造影用钡剂的评价

ASSESSMENT OF BARIUM PREPARATIONS FOR DOUBLE CONTRAST EXAMINATION OF THE STOMACH

胃部双重造影对胃部某些病变的检查,特别是早期胃癌的诊断,已成为不可缺少的一种方法,但国内尚缺少专用于胃双重造影的钡剂。六年来我们已试制成两种胃双重造影钡剂——华山200型钡剂(简称Ⅰ号)和医工-78型钡剂(简称Ⅱ号),经过四千余次的临床使用.

Double contrast examination of the stomach is an indispensable diagnostic procedure for various gastric diseases,especially early cancer.There was however no special barium preparations available in our country for this purpose.Such a barium mixture must fulfil the following criteria in vitro experiments before it can be applied to clinical studies:(1)Almost all of the barium particles are under 2 microns.(2)At a concentration of 120%(w/v),its viscosity is still under 100 oentipoises.(3)Coming in contact with acid or alkali,viscosity does not show significant change.(4)When one part of the preparation is mixed with an equal amount of acid gastric juice,barium does not agglutinate.During the past six years we have experimented and formulated two kinds of such preparations,namely SI and SII.Both of them could fulfill these criteria and found to be fairly satisfactory in more than four thousand clinical x-ray examinations.For further studies,a cross comparison with two kinds of Japanese products,namely JI(Barex-Coat-S)and JII(Barytgen de Luxe)was undertaken.Comparison of clinical use showed that SII was superior than JII,about equal with SI and JI.Mixed with gastric juice in vitro,JII agglutinated readily,when mixed with gas-producing and anti-foam medium,the viscosity of JII readily changed,indicating it was undesirable.SI had a poor resistance to acid and alkali and its viscosity modified distinctly after mixing with gastric juice and gas-producing anti-foam medium.When the concentration of the barium prepara-tions was over 160%(w/v),the viscosity of JI raised markedly while SII remained at a low level.Thus,it can be concluded that SII with optimal concentration of 150-180%(w/v)seems to be most suitable among the four barium preparations we have studied for double contrast examination of the stomach.