100例原发性肝癌乙型肝炎抗原和抗体的检测

DETECTION OF SERUM HBsAG HBsAB AND HBcAB IN 100 CASES OF PRIMARY LIVER CANCER

近年来,乙型肝炎抗原、抗体(HBsAg、RBsAb、HBcAb)已作为研究原发性肝癌(简称肝癌)患者感染乙型肝炎病毒的重要标志[1,2],特别是Macnab报道体外传代的人肝癌细胞株可以产生HBsAg.

Serological tests of HBsAg,HBsAb(Anti-HBs)and HBcAb(Anti-HBc)in 100 cases of primary liver cancer and in 18 cases of either tumors other than liver or chronic liver diseases,as controls were reported.The positive rate of these three tests in the group of liver cancer was 69.4%(68/98),6.4%(6/94)and 38.3%(18/47)and in the controls was 16.7%(3/18),11.1%(2/18)and 0%(0/18)respectively.The positive rate of HBsAg and HBcAb in primary liver cancer was obviously higher than that of the control(P<0.01).The finding revealed the positive rates of HBsAg and HBcAb in sera decreased gradually with the age.The positive rates of HBsAg and HBoAb were higher In the patients of liver cancer with cirrhosis than those without(P<0.05).AFP,history of hepatitis,SGPT and survival rate had no relation to the positive rate of the three tests.Two patients with liver cancer were investigated in family clustering of HBsAg and HBcAb.It was interesting to note that the family clustering was demonstrated both in those patients of the positive tests of HBsAg,HBcAb and those of liver cancer.It is our suggestion that the HBsAg may be regarded as a marker for the hepatitis B virus infection,and that the hepatitis B virus may provoke primary liver cancer through cryptogenic cirrhosis.Maternal vertical transmission suspected pathogenetically in the family clustering of liver cancer may be related to the genetic susceptibility of the hosts.In other words,the infection of hepatitis B virus and immune defect of genetic origin of the patients may be a pathogeny of the family clustering of the liver cancer.