人工肝、肾、解毒吸附剂的体外实验研究 Ⅰ.吸附剂的特性和效能

IN VITRO STUDIES ON ADSORBENTS EMPLOYED IN ARTIFICIAL LIVER, ARTIFICIAL KIDNEY AND HEMO-DETOXIFIER I. CHARACTERISTICS AND EFFICIENCY OF ADSORBENTS

1948年Muirhead租Reid应用树脂作人工肾,1964年Yatizidis用活性炭吸除血液中的毒物和代谢废物,首创了用吸附剂经血液灌流解毒的疗法,但都因血液有形成份受到严重损害而无法推广。

The efficiency of adsorbents employed in artificial liver,artificial kidney and hemo-detoxifier had been studied in vitro by means of nonperfusion and perfusion adsorption technics.Substrates such as pentobarbiturate,chlorpromazine,salicylate,cyanocobala-mine,bromosulphalein,urea,uric acid,creatinine,tryptophan,phenylalanine,tyro-sine,methionine,and free ammonia were chosen to assess the efficiency of different adsorbents.These could serve as parameters in removal of drug overdosage,middle molecular toxins,other uremic toxins and toxins of hepatic encephalopathy from the blood.Because of their simplicity and low cost we are convinced that non-perfusion tests greatly facilitate the screening of large numbers of samples for selection of suitable adsorbents from various sources as well as evaluation of the technic of micorencapsu-lation.Perfusion tests can be performed with much smaller quantities of adsorbents a9 well as perfusion fluid than reported in the literature.In addition these perfusion tests can be more closely simulate the actual clinical situation than the non-perfusion testa.The procedures and analytical methods were described in detail.