疫苗相关性葡萄膜炎的临床特征分析:基于美国疫苗不良事件报告系统的回顾性研究

Analysis of clinical characteristics of vaccine-associated uveitis:a retrospective study based on American vaccine adverse event reporting system

目的了解疫苗相关性葡萄膜炎的临床特征,为疫苗安全性监测、预防接种以及临床诊治提供参考。方法通过美国疫苗不良事件报告系统收集1990—2022年所有接种疫苗后发生葡萄膜炎的相关报告,并对接种者的性别、年龄、接种疫苗类型、疫苗剂次、葡萄膜炎发生时间以及葡萄膜炎类型进行回顾性分析。结果317例疫苗相关性葡萄膜炎病例中,共涉及10余种疫苗类型,主要为COVID-19疫苗、人乳头瘤病毒疫苗、乙型肝炎疫苗。男86例、女231例,男女比例为1∶2.7。18~<60岁接种者发生葡萄膜炎最多,占比65.3%。葡萄膜炎常见于接种疫苗后<8 d和第1剂疫苗接种后发生,分别占比56.8%和47.0%。184例葡萄膜炎类型分组报告中,虹膜睫状体炎占比最高,为56.5%。结论充分认识、深入研究接种疫苗的这一不良反应,持续开展疫苗安全性监测,更好进行预防接种以及临床诊治。

Objective To investigate the clinical characteristics of vaccine-associated uveitis in order to provide a reference for vaccine safety monitoring,vaccination,and clinical diagnosis and treatment.Methods The vaccine-associated uveitis reports from 1990 to 2022 were collected from the American Vaccine Adverse Event Reporting System.Moreover,sex,age,type of vaccination,dose series,time of occurrence,and type of uveitis of vaccine-associated uveitis reports were retrospectively analyzed.Results Of the 317 cases of vaccine-associated uveitis,more than 10 types of vaccine were involved,mainly the COVID-19 vaccine,human papillomavirus vaccine,and hepatitis B vaccine.There were 86 males and 231 females,with a male-to-female ratio of 1:2.7.Patients aged 18-<60 years,accounted for the majority of the total cases(65.3%).Uveitis is common under 8 days after vaccination and after the first dose of vaccination,accounting for 56.8%and 47.0%,respectively.Iridocyclitis represented the highest proportion of 184(56.5%)cases of uveitis.Conclusion Fully understand and study this adverse reaction to vaccination in depth,continue to monitor vaccine safety,better vaccination,and clinical diagnosis and treatment.