老年2型糖尿病患者轻度认知功能障碍的影响因素

Influencing factors of mild cognitive impairment in elderly patients with type 2 diabetes

目的 分析老年2型糖尿病患者轻度认知功能障碍(MCI)的影响因素,为制定针对性的干预措施提供参考。方法 采用便利抽样法,选取2021年11月至12月山东大学齐鲁医院老年2型糖尿病患者110例,分为MCI组(n=72)和非MCI组(n=38)。采用单因素和多因素非条件Logistic回归分析老年2型糖尿病患者MCI的影响因素。结果 110例老年2型糖尿病患者中,患MCI者72例(65.45%)。MCI组、非MCI组患者的年龄、文化程度、家庭月收入、糖尿病病程、睡前血糖差异均有统计学意义(P均<0.05)。多因素非条件Logistic回归分析结果显示,家庭月收入(OR=0.236,95%CI:0.096~0.581)、糖尿病病程(OR=1.077,95%CI:1.005~1.154)、睡前血糖水平(OR=1.213,95%CI:1.030~1.428)是老年2型糖尿病患者MCI的影响因素(P=0.002,P=0.036,P=0.020)。结论 老年2型糖尿病患者MCI患病率较高,家庭月收入低、糖尿病病程长、睡前血糖高可能会增加MCI的发生风险,应予以重点关注。

Objective To analyze the influencing factors of mild cognitive impairment(MCI) in elderly patients with type 2 diabetes, and to provide reference for the development of targeted intervention measures. Methods A total of 110 elderly patients with type 2 diabetes were selected with convenience sampling method during Nov. and Dec. 2021, and divided into MCI group and non-MCI group. The influencing factors of MCI were analyzed with univariate and multivariate non-conditional Logistic regression. Results Of the 110 patients, 72(65.45%) had MCI. There were statistically significant differences in age, education level, monthly family income, duration of diabetes and blood glucose before bedtime between MCI group and non-MCI group(P<0.05). Multivariate Logistic regression analysis showed that the monthly family income(OR=0.236, 95%CI: 0.096-0.581), duration of diabetes(OR=1.077, 95%CI: 1.005-1.154), and blood glucose before bedtime(OR=1.213, 95%CI: 1.030-1.428) were the influencing factors of MCI(P=0.002, P=0.036, P=0.020). Conclusion The prevalence of MCI in patients with type 2 diabetes is high. Low family monthly income, long course of diabetes and high blood glucose before bedtime may increase the risk of MCI and should arouse attention.