探寻一家系短期3例胃癌的临床病理及其相关肿瘤特征

Exploring the clinicopathological features of three cases of gastric cancer in one pedigree during short-term

目的 总结家族聚集性胃癌(FGC)的临床特征,为其防治提供一定的参考价值。方法 回顾性收集2016年12月至2022年1月收治的同一家系兄弟姐妹3人先后患胃癌的临床资料,分析其一般情况、临床特点、治疗及转归,并随访至2022年3月。结果 胃癌在此家系中呈聚集性发病,其中男2例、女1例,发病时平均年龄47岁,3例患者具有共同的生活及饮食习惯,符合FGC的诊断,明确诊断后均接受手术及术后化疗,现1例患者已故,另外2例患者定期复查。结论 FGC的发病率较低,本文报道的短期内同一家系兄弟姐妹3人先后都患胃癌更为罕见,因此,家族中有超过2人患胃癌时,一定要注意预防FGC的发生。

Objective To summarize the clinical features of familial clustered gastric cancer to provide reference for the prevention and treatment. Methods The clinical data of 3 brothers and sisters from the same family admitted during Dec. 2016 and Jan. 2022 due to gastric cancer were retrospectively collected. The general condition, clinical characteristics, treatment and outcomes were analyzed. All patients were followed up until March 2022. Results Gastric cancer was clustered in this family, including 2 males and 1 female, with an average age of 47 years at the time of onset. The 3 patients had common living and eating habits, which were in line with the diagnosis of familial clustered gastric cancer. After surgery and postoperative chemotherapy, 1 patient was deceased, and the other 2 were regularly followed up. Conclusion The incidence of familial clustered gastric cancer is relatively low. It is rare that all three siblings in the same family have gastric cancer in a short period of time. Therefore, when there are more than 2 people in the family suffering from gastric cancer, familial aggregation of gastric cancer must be alerted.