2809名体检人群中高血压与幽门螺杆菌感染的关联性

Correlation of helicobacter pylori infection and hypertension in the 2,809 physical examination participants

目的探讨体检人群中高血压与幽门螺杆菌(Hp)感染的关联性,为高血压防治提供理论依据。方法选取2021年1月~6月进行体检的人员2809例,进行^(13)C-尿素呼气试验、血压及空腹血液等检查。根据检查结果将体检人员分为高血压组(n=485例)和非高血压组(n=2324例)。比较两组Hp感染率,采用多元线性回归分析Hp感染与收缩压、舒张压、平均动脉压、脉压的关联性,采用多因素Logistic回归分析高血压的危险因素。结果高血压组Hp感染率显著高于非高血压组(P<0.001);多元线性回归分析结果显示,Hp感染与舒张压(β=0.862,95%CI:0.019~1.706,P=0.045)、平均动脉压(β=0.975,95%CI:0.074~1.876,P=0.034)呈正相关;多因素Logistic回归分析显示,Hp感染是高血压的独立危险因素(OR=1.667,95%CI:1.324~2.099,P<0.001)。结论Hp感染与舒张压、平均动脉压水平密切相关,可明显增加高血压的患病风险,提示积极控制Hp感染有利于预防或减少高血压的发生。

Objective To explore the association between helicobacter pylori(Hp)infection and hypertension in the physical examination population,in order to provide a theoretical basis for the prevention and treatment of hypertension.Methods This cross-sectional study involved 2,809 participants who underwent^(13)C-urea breath test,blood pressure and fasting blood examination during January 2021 and June 2021.The participants were divided into hypertensive group(n=485)and non-hypertensive group(n=2324)according to the examination results.The incidence of Hp infection was compared between two groups.The correlation of Hp infection with systolic pressure,diastolic pressure,mean arterial pressure,and pulse pressure was analyzed with multiple linear regression.The risk factors for hypertension were analyzed with multivariate Logistic regression.Results The incidence of Hp infection was significantly higher in the hypertensive group than in the non-hypertensive group(P<0.001).Multiple linear regression showed that Hp infection was positively associated with diastolic pressure(β=0.862,95%CI:0.019-1.706,P=0.045)and mean arterial pressure(β=0.975,95%CI:0.074-1.876,P=0.034).Multivariate Logistic regression showed that Hp infection was an independent risk factor for hypertension(OR=1.667,95%CI:1.324-2.099,P<0.001).Conclusion Hp infection is closely associated with diastolic blood pressure and mean arterial pressure,which can significantly increase the risk of hypertension,suggesting that active control of Hp infection is beneficial to preventing or reducing the incidence of hypertension.