温阳散寒活血法治疗下肢动脉硬化闭塞症疗效及血清hsCRP、TNF-α、IL-6的影响

Curative Effect of Warming Yang,Dispersing Cold and Invigorating Blood Circulation in Treating Arteriosclerosis Obliterans of Lower Limbs and Influence of Serum hsCRP,TNF-α,IL-6

目的:探讨温阳散寒活血法治疗下肢动脉硬化闭塞症(ASO)疗效及血清超敏C反应蛋白(hsCRP)、肿瘤坏死因子-α(TNF-α)、白介素-6(IL-6)的影响。方法:选取2018年1月~2020年12月河北省沧州中西医结合医院收治的180例ASO患者,根据随机数字表法分为两组,对照组(n=90)接受常规西医治疗,观察组(n=90)在常规西医治疗基础上接受自拟脉管炎Ⅰ号组方熏洗治疗。比较两组患者临床疗效和治疗14d、28d后中医证候积分、间歇性跛行距离、踝肱指数、足背动脉血流量和血清hsCRP、TNF-α、IL-6水平及不良反应发生情况。结果:观察组临床治疗总有效率明显高于对照组(P<0.05)。治疗后14d、28d观察组中医证候积分和血清hsCRP、TNF-α、IL-6水平明显低于对照组,间歇性跛行距离、踝肱指数、足背动脉血流量明显高于对照组(P<0.05)。两组患者不良反应发生率比较无差异(P>0.05)。结论:自拟脉管炎Ⅰ号组方熏洗治疗ASO疗效显著,可有效改善下肢缺血症状,延长间歇性跛行距离,调节血清hsCRP、TNF-α、IL-6水平,且安全性高,值得推广。

Objective:The objective of this study is to investigate the efficacy of warming yang,dispersing cold and invigorating blood in the treatment of lower limb atherosclerosis occlusive disease(ASO)and its effect on serum ultrasensitive C-reactive protein(hsCRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6).Methods:A total of 180 patients with ASO admitted to Cangzhou Hospital of Traditional Chinese and Western Medicine in Hebei Province between January 2018 and December 2020 were selected and randomly divided into two groups using the random number table method.The control group(n=90)received conventional western medical treatment,while the observation group(n=90)received self-prepared Vasculitis I group formula fumigation treatment in addition to conventional western medical treatment.The clinical efficacy,TCM symptom score,intermittent claudication distance,ankle-brachial index,dorsalis pedis artery blood flow,serum hsCRP,TNF-α,IL-6 levels,and the occurrence of adverse reactions were compared between the two groups after 14 and 28 days of treatment.Results:The total clinical treatment efficiency of the observation group was significantly higher than that of the control group(P<0.05).The TCM symptom score and serum hsCRP,TNF-α,and IL-6 levels in the observation group were significantly lower than those in the control group at 14 and 28 days after treatment,and the intermittent claudication distance,ankle-brachial index,and dorsalis pedis artery blood flow were significantly higher than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:The treatment of ASO with self-prepared Vasculitis I group formula fumigation has significant efficacy,can effectively improve the symptoms of lower limb ischemia,prolong the intermittent claudication distance,regulate the serum hsCRP,TNF-α,and IL-6 levels,and has high safety.This treatment option is worth promoting.