中药联合5-氨基酮戊酸光动力治疗尖锐湿疣的效果及对血清ICAM-1和IFN-γ水平的影响

The effect of traditional Chinese medicine combined with 5-aminolevulinic acid photodynamic therapy on condyloma acuminatum and its effect on serum ICAM-1 and IFN-γlevels

目的:探究中药联合5-氨基酮丙酸光动力对尖锐湿疣的治疗效果,并分析该联合治疗对患者血清细胞间黏附因子-1(ICAM-1)以及干扰素-γ(IFN-γ)的影响;方法:选择2019年1月~2020年7月青海省第四人民医院收治的200例尖锐湿疣患者为研究对象,按照治疗方法不同分为对照组和研究组,各100例,对照组采用传统5-氨基酮丙酸光动力治疗,研究组采用中药联合5-氨基酮丙酸光动力治疗,对比两组患者治疗疗效、随访3个月复发情况、治疗前后ICAM-1及IFN-γ水平变化以及不良反应发生率;结果:(1)研究组治疗总有效率为97.0%(97/100),显著高于对照组的86.0%(86/100),随访3个月后,研究组有5例复发,对照组有18例复发,研究组复发率显著低于对照组,差异均有统计学意义(P<0.05);(2)治疗前两组患者血清ICAM-1、IFN-γ水平比较,差异无统计学意义(P>0.05),治疗后研究组患者ICAM-1水平明显低于对照组,IFN-γ明显高于对照组(P<0.05);(3)研究组治疗后不良反应率为2%,与对照组的7%比较,差异无统计学意义(P>0.05)。结论:中药联合5-氨基酮丙酸光动力对尖锐湿疣治疗效果较好,临床疗效确切,复发率低,治疗后血清因子变化明显,且不良反应发生率更低,值得临床推广应用。

Objective To explore the therapeutic effect of traditional Chinese medicine combined with 5-aminoketopropionic acid photodynamics on condyloma acuminatum,and to analyze the effect of treatment on the patient's serum intercellular adhesion factor-1(ICAM-1)and interferon-γ(IFN-γ);Methods 200 patients with condyloma acuminatum admitted to the Fourth People's Hospital of Qinghai Province from January 2019 to July 2020 were Selected as the research objects,and were divided into a control group and a study group according to the different treatment methods,with 100 cases in each group.The control group adopts traditional 5-aminoketopropionic acid photodynamic therapy,the study group used traditional Chinese medicine combined with 5-aminoketopropionic acid photodynamic therapy.The treatment efficacy,recurrence at 3 months follow-up,changes in ICAM-1 and IFN-γlevels before and after treatment,and the incidence of adverse reactions were compared between the two groups;Results(1)The total effective rate of treatment in the study group was 97.0%(97/100),which was significantly higher than 86.0%(86/100)in the control group.After 3 months of follow-up,there were 5 cases of recurrence in the study group and 18 cases in the control group,the recurrence rate of the study group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05);(2)Before treatment,there was no significant difference in the levels of ICAM-1 and IFN-γbetween the two groups(P>0.05).After treatment,the level of ICAM-1 in the study group was significantly lower than that of the control group,and IFN-γwas significantly higher than that of the control group(P<0.05);(3)There was no significant difference in the rate of adverse reactions between the study group(2%)and the control group(7%).Conclusion Traditional Chinese medicine combined with 5-aminoketopropionic acid photodynamics has a good therapeutic effect on condyloma acuminatum,with definite clinical curative effect,low recurrence rate,obvious changes in serum factors after treatment,and lower incidence of adverse reactions.It is worthy of clinical application.