理气益肾安神汤加减治疗慢性肾衰竭伴睡眠障碍脾肾两虚证女性患者临床观察

Clinical Observation of Using Modified Liqi Yishen Anshen Decoction in the Treatment of Female Patients with Chronic Renal Failure Complicated with Sleep Disorders of Spleen-kidney Deficiency Syndrome

目的:探讨给予慢性肾衰竭伴睡眠障碍脾肾两虚证女性患者理气益肾安神汤加减治疗对其生活质量的影响。方法:选取2016年11月~2019年11月本院收治的88例慢性肾衰竭伴睡眠障碍女性患者,随机数字表法分为观察组和对照组各44例,对照组给予常规治疗,观察组在此基础上加以理气益肾安神汤加减治疗,比较两组临床疗效、肾功能(尿素氮、血肌酐、肌酐清除率)、匹兹堡睡眠质量指数(PSQI)评分以及生活质量。结果:观察组临床有效率88.64%高于对照组的70.45%(P<0.05);观察组干预后肾功能尿素氮、血肌酐、肌酐清除率指标水平及PSQI评分均优于对照组(P<0.05);观察组干预后生活质量评分显著高于对照组(P<0.05)。结论:给予慢性肾衰竭伴睡眠障碍脾肾两虚证女性患者理气益肾安神汤加减治疗临床效果好,可明显改善患者肾功能及睡眠障碍,提高生活质量。

Objective:To investigate the effect of using Modified Liqi Yishen Anshen Decoction in the treatment of female patients with chronic renal failure complicated with sleep disorders and spleen-kidney deficiency syndrome.Methods:88 female patients with chronic renal failure and sleep disorders who were admitted and treated in the hospital between November 2016 and November 2019 were divided into an observation group and a controlled group by the random number table method,44 cases in each group.Both groups were given routine treatment and the observation group was additionally treated with Modified Liqi Yishen Anshen Decoction.The clinical effect,renal function(urea nitrogen,serum creatinine and creatinine clearance rate),Pittsburgh Sleep Quality Index(PSQI)scores and quality of life were compared between the two groups.Results:The clinical effective rate of the observation group(88.64%)was higher than that of the controlled group(70.45%)(P<0.05).After intervention,urea nitrogen,serum creatinine,creatinine clearance rate and PSQI score of the observation group were better than those of the controlled group(P<0.05),and the quality of life score was significantly higher than that of the controlled group(P<0.05).Conclusion:Modified Liqi Yishen Anshen Decoction is effective in the treatment of female patients with chronic kidney failure complicated with sleep disorders and spleen-kidney deficiency syndrome.It can significantly improve the patient’s renal function,sleep disorders and quality of life.