前列清瘀汤联合西药治疗慢性前列腺炎(湿热瘀滞证)对患者EPS中MCP-1、M-CSF水平影响分析

Effect of Qianlie Qingyu Decoction Combined with Western Medicine on Chronic Prostatitis (Dampness-heat Stasis Syndrome) on the Levels of MCP-1and M-CSF for EPS

目的:观察前列清瘀汤联合西药治疗慢性前列腺炎(湿热瘀滞证)对患者前列腺液(EPS)中单核细胞趋化蛋白-1(MCP-1)、巨噬细胞集落刺激因子(M-CSF)水平影响,为临床治疗提供参考。方法:选取我院2017年12月~2019年10月收治的慢性前列腺炎(湿热瘀滞证)患者142例,根据治疗方法分为两组,每组71例。西医组给予常规西药治疗,联合组给予前列清瘀汤联合西药治疗。记录两组治疗前后EPS中细胞因子水平及慢性前列腺炎症状(NIH-CPSI)评分、尿流率水平变化,并统计两组临床治疗总有效率。结果:治疗后,联合组总有效率(92.96%)高于西医组(81.69%),差异具有统计学意义(P<0.05)。治疗后,两组EPS中MCP-1、M-CSF、血管细胞黏附分子~1(VCAM-1)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(TNF-α)水平及NIH-CPSI评分较治疗前下降,最大尿流率、平均尿流率较治疗前上升,联合组EPS中MCP-1、M-CSF、VCAM-1、IL-10、TNF-α水平及NIH-CPSI评分低于西医组,最大尿流率、平均尿流率高于西医组(P<0.05)。结论:前列清瘀汤联合西药治疗慢性前列腺炎(湿热瘀滞证)可调节相关因子的表达,提高尿流率,改善临床症状。

Objective:To observe the effect of Qianlie Qingyu Decoction combined with western medicine on the level of monocyte chemotactic protein-1(MCP-1)and macrophage colony stimulating factor(M-CSF)for patients with chronic prostatitis(damp-heat stasis syndrome)for prostate fluid(EPS)for clinical treatment.Methods:Selecting 142 patients with chronic prostatitis(dampness-heat stasis syndrome)treated in our hospital(from December 2017 to October 2019),divided into 2 groups according to the treatment method,71 cases in each group.The western medicine group was given routine western medicine treatment,the combined group was given Qianlie Qingyu Decoction combined with western medicine treatment.Cytokine levels and chronic prostatitis symptoms(NIH-CPSI)scores,urinary flow rate changes in EPS before and after treatment in the 2 groups were recorded,and the total effective rate of clinical treatment in the 2 groups were counted.Results:After treatment,the total effective rate of the combined group(92.96%)was higher than that of the western medicine group(81.69%),and the difference was statistically significant(P<0.05).After treatment,the levels of MCP-1,M-CSF,vascular cell adhesion molecule-1(VCAM-1),interleukin-10(IL-10),tumor necrosis factor-α(TNF-α)and NIH-CPSI in the two groups of EPS were decreased compared with that before treatment,the maximum urinary flow rate and the average urinary flow rate were higher than that before treatment.In the combined group,the levels of MCP-1,M-CSF,VCAM-1,IL-10,TNF-α water were increased and NIH-CPSI scores were lower than those in the western medicine group,and the maximum and average urinary flow rates were higher than those in the western medicine group(P<0.05).Conclusion:The treatment of chronic prostatitis(dampness-heat stasis syndrome)can regulate the expression of related factors,improve the urine flow rate and improve the clinical symptoms.