妊娠期高血压病血浆microRNA-126水平与中医证候及体质分布关系研究

Study on Relationship between Plasma microRNA-126 Level and Traditional Chinese Medicine Syndromes and Constitution Distribution of Hypertensive Disorder Complicating Pregnancy

目的:分析研究妊娠期高血压病血浆microRNA-126水平与中医证候及体质分布的关系。方法:选择2017年12月~2019年12月于医院产科住院治疗妊娠期高血压177例(妊娠期高血压组)、子痫前期102例(子痫前期组)和重度子痫前期82例(重度子痫前期组),判定其中医证候及体质分布情况,同时收集同期于医院检查的健康孕妇30例(正常组),检测各组血浆microRNA-126水平,并分析血浆microRNA-126水平与中医证候及体质分布的关系。结果:妊娠高血压组患者以脾虚湿盛证为主,子痫前期组、重度子痫前期组患者以脾虚肝旺证和阴虚肝旺证为主,各患者中医体质分布以气虚质、阴虚质为主,其次为阳虚质、痰湿质和湿热质,各组患者中医证候及体质分布比较,差异有统计学意义(P<0.05);不同中医证候妊娠期高血压病患者中医体质分布比较,差异有统计学意义(P<0.05);妊娠期高血压病患者血浆microRNA-126水平明显低于正常妊娠组(P<0.05),且表现为脾虚湿盛证组<肾虚水泛证组<脾虚肝旺证组<阴虚肝旺证组(P<0.05)。结论:妊娠期高血压病患者以脾虚肝旺证为主,其次为脾虚湿盛证和阴虚肝旺证,中医体质以气虚质和阴虚质为主,患者中医证候与其中医体质之间存在密切联系,不同中医证候临床表现与患者血浆microRNA-126水平降低有关。

Objective:To analyze and study the relationship between plasma microRNA-126 level and TCM syndromes and constitution distribution of hypertensive disorder complicating pregnancy.Methods:From December 2017 to December 2019,177 cases of pregnancy-induced hypertension(pregnancy-induced hypertension group),102 cases of preeclampsia(preeclampsia group)and 82 cases of severe preeclampsia(severe preeclampsia group)were hospitalized in the department of obstetrics of the hospital.The TCM syndromes and constitution distribution were determined.30 healthy pregnant women who were checked in the hospital during the same period were collected(normal group).The plasma microRNA-126 level was detected in each group,and the relationship between plasma microRNA-126 level and TCM syndromes and constitution distribution was analyzed.Results:The pregnancy-induced hypertension group was mainly composed of spleen deficiency and dampness overabundance syndrome while the preeclampsia group and the severe preeclampsia group were mainly composed of spleen deficiency and liver flourishing syndrome and Yin deficiency and liver flourishing syndrome,and the TCM constitution distribution status of patients were mainly Qi deficiency constitution and Yin deficiency constitution,followed by Yang deficiency constitution,phlegm-dampness constitution and damp-heat constitution.Comparison of TCM syndromes and constitution distribution among each group showed statistical significance(P<0.05).There were statistically significant differences in the TCM constitution distribution of patients with hypertensive disorder complicating pregnancy of different TCM syndromes(P<0.05).The plasma microRNA-126 level in patients with hypertensive disorder complicating pregnancy was significantly lower than that in the normal pregnancy group(P<0.05),manifested as the spleen deficiency and dampness overabundance syndrome grouP<the kidney deficiency and edema syndrome grouP<the spleen deficiency and liver flourishing syndrome grouP<the Yin deficiency and liver flourishing syndrome group(P<0.05).Conclusion:Patients with hypertensive disorder complicating pregnancy are mainly composed of spleen deficiency and liver flourishing syndrome,followed by spleen deficiency and dampness overabundance syndrome and Yin deficiency and liver flourishing syndrome.TCM constitution is mainly Qi deficiency constitution and Yin deficiency constitution,and TCM syndromes were closely related to TCM constitution,and the clinical manifestations of different TCM syndromes are related to the decrease of plasma microRNA-126 level in patients.