祛瘀明目汤联合羟苯磺酸钙对糖尿病视网膜病变患者疗效及血清VEGF和FGF21水平影响

Effect of Quyu Mingmu Decoction combined with calcium dobesilate on serum VEGF and FGF21 levels in patients with diabetes retinopathy

目的:探讨祛瘀明目汤联合羟苯磺酸钙对糖尿病视网膜病变(DR)患者疗效及血清VEGF和FGF21水平影响。方法:选择我院于2021年9月~2023年9月收治的DR患者108例,运用随机数字表法分为治疗组(n=54)与对照组(n=54)。对照组口服羟苯磺酸钙分散片,治疗组在对照组基础上服用祛瘀明目汤。两组疗程3个月。比较两组治疗疗效,治疗前后视力和视野平均缺损程度、视网膜病变、视网膜血流动力学、VEGF和FGF21水平,及不良反应。结果:治疗组DR患者治疗总有效率高于对照组(P<0.05)。两组治疗后DR患者视力高于治疗前,而视野平均缺损程度低于治疗前(P<0.05);治疗组治疗后DR患者视力高于对照组,而视野平均缺损程度低于对照组(P<0.05)。两组治疗后DR患者出血斑面积、血管瘤和黄斑厚度低于治疗前(P<0.05);治疗组治疗后DR患者出血斑面积、血管瘤和黄斑厚度低于对照组(P<0.05)。两组治疗后DR患者PSV高于治疗前,而RI低于治疗前(P<0.05);治疗组治疗后DR患者PSV高于对照组,而RI低于对照组(P<0.05)。两组治疗后DR患者血清VEGF和FGF21水平低于治疗前(P<0.05);治疗组治疗后DR患者血清VEGF和FGF21水平低于对照组(P<0.05)。治疗组不良反应少于对照组(P<0.05)。结论:祛瘀明目汤联合羟苯磺酸钙对DR患者疗效显著,且可降低血清VEGF和FGF21水平,值得临床借鉴。

Objective:To explore the therapeutic effect of Quyu Mingmu Decoction combined with calcium dobesilate on diabetes retinopathy(DR)and the influence of serum vascular endothelial growth factor(VEGF)and fibroblast growth factor 21(FGF21)levels.Methods:108 DR patients admitted to our hospital from September 2021 to September 2023 divided treatment group(n=54)and a control group(n=54).The control group was treated with calcium hydroxybenzenesulfonate dispersible tablets,while the treatment group received Quyu Mingmu Decoction basis of control group.The treatment course for two groups is 3 months.Compare the therapeutic effects of two groups,including the average degree of visual and field defects,retinal lesions,retinal hemodynamics,VEGF and FGF21 levels of before and after treatment,and adverse reactions.Results:The treatment group effective rate of DR patients higher control group(P<0.05).After treatment,two groups visual acuity of DR patients higher before treatment,while the average degree of visual field defect lower before treatment(P<0.05);treatment group visual acuity of DR patients higher control group,while the average degree of visual field defect lower control group(P<0.05).After treatment,two groups bleeding spot area,hemangioma,and macular thickness of DR patients lower before treatment(P<0.05);treatment group bleeding spot area,hemangioma,and macular thickness of DR patients lower control group(P<0.05).After treatment,two groups PSV of DR patients higher before treatment,while the RI lower before treatment(P<0.05);treatment group PSV of DR patients higher control group,while the RI lower control group(P<0.05).After treatment,two groups serum levels of VEGF and FGF21 in DR patients lower before treatment(P<0.05);treatment group serum levels of VEGF and FGF21 in DR patients lower control group(P<0.05).The treatment group adverse reactions less control group(P<0.05).Conclusion:The combination of Quyu Mingmu Decoction and calcium hydroxybenzenesulfonate has a significant therapeutic effect on DR patients,and can reduce serum VEGF and FGF21 levels,which is worthy of clinical reference.