血常规炎症标志物对子宫内膜异位症诊断及病情评估的价值研究

The value of blood routine inflammatory markers in the diagnosis and evaluation of endometriosis

研究血常规炎症标志物对子宫内膜异位症(EMs)诊断及病情评估的价值。本文选择2007年6月至2021年4月期间在我院经腹腔镜手术确诊的EMs患者作为EMs组,同期体检的健康女性作为对照组,比较2组间血常规炎症标志物中性粒细胞与淋巴细胞比值(NLR)、淋巴细胞与单核细胞比值(LMR)、血小板与淋巴细胞(PLR)、全身免疫炎症指数(SII)及超敏C反应蛋白(hs-CRP)的差异,在logistic回归分析中得到炎症标志物的回归方程并作为联合指标,采用ROC曲线分析单独或联合使用炎症标志物对EMs的诊断价值及病情的评估价值。研究结果中EMs组的NLR、PLR、SII、hs-CRP水平均高于对照组,LMR的水平低于对照组(P<0.05);EMs中III-IV期患者的NLR、PLR、SII、hs-CRP水平均高于I-II期患者,LMR的水平低于I-II期患者(P<0.05);单独使用NLR、PLR、LMR、SII、hs-CRP均对EMs具有诊断价值、对轻度和重度EMs具有评估价值;将logistic回归分析得到的方程作为联合指标,对EMs具有诊断价值、对轻度和重度EMs具有评估价值,且诊断疾病的效能及评估病情的效能均优于单一指标。因此,联合使用血常规炎症标志物NLR、PLR、LMR、SII、hs-CRP能够为EMs的诊断及病情的评估提供依据。

To investigate the value of blood routine inflammatory markers in the diagnosis and evaluation of endometriosis(EMs).In this study,EMs patients diagnosed by laparoscopic surgery in our hospital from June 2007 to April 2021 were selected as the EMs group,and healthy women who underwent physical examination during the same period were selected as the control group.The differences of neutrophil to lymphocyte ratio(NLR),lymphocyte to monocyte ratio(LMR),platelet to lymphocyte(PLR),systemic immunoinflammatory index(SII)and hypersensitive C-reactive protein(hs-CRP)among the two groups were compared.The regression equation of inflammatory markers was obtained in logistic regression analysis and used as a joint indicator.ROC curve was used to analyze the diagnostic value and disease assessment value of single or combined inflammatory markers in EMs.The levels of NLR,PLR,SII and hs-CRP in EMs group were higher than those in control group,and the levels of LMR were lower than those in control group(P<0.05).In EMs,the levels of NLR,PLR,SII and hs-CRP in stage III-IV patients were higher than those in stage I-II patients,and the levels of LMR were lower than those in stage I-II patients(P<0.05).The use of NLR,PLR,LMR,SII and hs-CRP alone has diagnostic value for EMs,and evaluation value for mild and severe EMs.Using the equation obtained from logistic regression analysis as a joint index,it has diagnostic value for EMs,and has evaluation value for mild and severe EMs,and the efficacy of disease diagnosis and disease evaluation is better than that of a single index.Therefore,the combined use of blood routine inflammatory markers NLR,PLR,LMR,SII and hs-CRP can provide a basis for the diagnosis of EMs and the evaluation of the disease.