中性粒细胞淋巴细胞比值、脂蛋白相关磷脂酶A2与2型糖尿病伴冠心病的相关性研究

Correlation between neutrophil lymphocyte ratio,lipoprotein associated phospholipase A2 and type 2 diabetes mellitus with coronary heart disease

目的:探讨中性粒细胞淋巴细胞比值(neutrophil-lymphocyte ratio, NLR)、脂蛋白相关磷脂酶A2(lipoprotein associated phospholipase A2,Lp-PLA2)与2型糖尿病(type 2 diabetes mellitus, T2DM)伴冠心病(coronary artery disease, CAD)的相关性。方法:前瞻性选取2020年01月20日至2021年6月18日在海安市人民医院接受治疗的70例T2DM患者作为研究对象,根据是否合并CAD分为T2DM组和T2DM+CAD组,再选取同期接受体检的35例健康体检者作为对照观察(Control组)。收集研究对象的一般资料及实验室指标,采用多因素Logistic回归分析T2DM并发CAD的危险因素,并采用ROC曲线分析NLR和Lp-PLA2的预测价值。结果多因素Logistic回归分析显示,CHR(OR=1.028)、NLR(OR=9.263)、Lp-PLA2(OR=4.152)是T2DM伴CAD的独立危险因素(均P<0.05);ROC曲线显示,NLR、Lp-PLA2联合预测的诊断效能较高,其AUC为0.950,敏感性为85.26%,特异性为89.06%。结论:NLR、Lp-PLA2可能是T2DM伴CAD的预测指标,可能可用于鉴别诊断合并CAD的T2DM患者。

Objective:To investigate the relationship of neutrophil to lymphocyte ratio(NLR)and lipoprotein-associated phospholipase A2(Lp-PLA2)with type 2 diabetes mellitus(T2DM)complicated with coronary artery disease(CAD).Methods:70 patients with T2DM who were treated in Hai'an People's Hospital from January 20.2020 to June 18.2021 were prospectively selected as the research object,and were divided into T2DM group and T2DM+CAD group according to whether CAD was combined or not.and then 35 healthy people who received physical examination in the same period were selected as the Control group.The general data and laboratory indexes of the subjects were collected,the risk factors of T2DM complicated with CAD were analyzed by multivariate Logistic regression,and the predictive value of NLR and Lp-PLA2 was analyzed by ROC curve.Results:Multivariate Logistic regression analysis showed that CHR(OR=1.028).NLR(OR=9.263)and Lp-PLA2(OR=4.152)were independent risk factors for T2DM with CAD(all P<0.05).ROC curve shows that the diagnostic efficiency of NLR and Lp-PLA2 combined prediction is high,with AUC of 0.950.sensitivity of 85.26%and specificity of 89.06%.Conclusions;NLR and Lp-PLA2 may be predictors of T2DM with CAD.and may be used to differentiate T2DM patients with CAD.