miR92a-3p-miR25-3p-EZH2通路调控模拟微重力致神经炎症的机理研究

Mechanism of miR92a-3p-miR25-3p-EZH2 pathway inregulating neuroinflammation induced by simulated spacemicrogravity environment

空间微重力是对人体功能产生不利影响的重要环境因素,在空间环境中神经细胞将会出现神经炎症,同时胞内外环境及内部调控因子会出现相应变化。本文主要探究了模拟空间微重力环境下星形胶质细胞胞内外神经炎症相关调控miRNA含量及炎症因子的变化,并对其中可能存在的调控机理进行分析。结果显示,组蛋白赖氨酸甲基转移酶(EZH2)对胶质细胞炎性活化起到关键作用,并与miR92a-3p、miR25-3p有着相互调控的关系,揭示了miR92a-3p、miR25-3p和EZH2信号调控途径与微重力条件胶质细胞的神经炎症自适应密切相关。

Space microgravity is an important environmental factor that adversely affects human body function.Neuroinflammation will occur in nerve cells in the space environment,and the intracellular and extracellular environment and internal regulatory factors will change accordingly.This paper mainly explores the changes of intracellular and extracellular regulatory miRNA content and inflammatory factors in astrocytes under simulated space microgravity environment,and analyzes the possible regulatory mechanisms.The results showed that histone lysine methyltransferase(EZH2)plays a key role in neuroinflammation process,and has a mutual regulatory relationship with miR92a-3p and miR25-3p,miRNA also has a regulatory effect on autonomic neuronal modulation of inflammation induced by microgravity.