药物外治法的进展以及在神经变性疾病中的应用

Progress in external therapy and its application in neurodegenerative diseases

药物外治法作为体外给药的一种方式,既能避免首过效应,也可对偏于体表或深入骨骼肌肉的疾病起到更直接的作用,同时有稳定持续释放药量的优势。膏药作为一种最常用的外治方法,成分较为复杂,经过皮肤屏障吸收进入体内的成分与口服药物有所不同,如何使更多药量透过皮肤屏障,如何检测进入人体的药物成分与浓度仍是目前外用膏药质控面临的主要问题。本文总结了药物外治、特别是膏药使用的历史沿革,通过查阅近年相关文献,对提升外用贴膏透皮率的促透剂及方法技术进行总结,并介绍了检测药物透皮率的实验方法。总结了外用膏药的给药优势,介绍了药物贴膏在神经变性疾病中的创新使用。期望为改良、创新外用贴膏的生产和使用提供思路。

As a kind of transdermal drug delivery systems,external therapy can avoid first pass effect.It also has an advantage of releasing medicament steadily and direct acting on body surface,skeleton and muscle.As a common external therapy,plasters have complicated ingredients.The elements in plasters also absorb into the body in a different way from oral drug.How to make more drug penetrate through the skin as well as test the elements and concentrations that enter the body are still the main problems that quality control of plasters facing.The article summarizes the history of external therapy,particularly the plasters.Based on the researches in recent years,the article generalizes the penetration enhancers and methods which can promote the penetration rate and the way to detect the penetrate rate.The author introduces the advantages and usages of plasters in neurodegenerative diseases and hopes to provide brand new thinking that can help to improve the productions and uses of plasters.