高尔基体蛋白73在肝硬化中表达水平的临床意义及与影像学指标的关系

Clinical significance of Golgi protein 73 in liver cirrhosis and its relationship with radiological parameters

目的探讨血清高尔基体蛋白73(GP73)与肝硬化的临床意义及与影像学指标的关系。方法选择2016年1月至2018年12月吉林大学第一医院收治肝硬化患者177例,慢性肝炎患者61例,选择同期70例健康体格检查者为对照组。比较GP73、丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天冬氨酸氨基转移酶(aspartate aminotransferase,AST)、血清白蛋白(albumin,ALB)、总胆红素(total bilirubin,TBIL)、凝血酶原时间(prothrombin time,PT)及门静脉主干直径在肝硬化患者、慢性肝炎患者及健康人群之间的差异;根据不同分类标准,比较肝硬化各亚组GP73水平的差异;分析各组GP73与ALT、AST、ALB、TBIL、PT及门静脉主干直径之间的相关性。结果肝硬化组的GP73水平较慢性肝炎组与对照组明显升高(P<0.001)。失代偿期肝硬化组血清GP73水平明显高于代偿期肝硬化组(P<0.001);Child-pugh B级与Child-pugh C级肝硬化组血清GP73水平明显高于Child-pugh A级肝硬化组(P<0.05)。肝硬化组GP73水平均与血清AST、ALT、TBIl、PT及门静脉主干直径呈正相关;与ALB呈负相关。结论血清GP73在肝硬化组表达升高,与肝功能损伤指标密切相关,血清GP73对肝硬化的早期诊断及预后的评估具有重要临床应用价值。

Objective To explore the clinical significance of serum Golgi protein 73(GP73)in liver cirrhosis and its association with radiological parameters.Methods We included 177 patients with liver cirrhosis and 61 patients with chronic hepatitis admitted to The First Hospital of Jilin University from January 2016 to December 2018,with 70 healthy subjects who underwent physical examination during the same period as the control.We compared GP73,alanine transaminase(ALT),aspartate transaminase(AST),albumin(ALB),total bilirubin(TBIL),prothrombin time(PT),and main portal vein diameter between the patients with liver cirrhosis,patients with chronic hepatitis,and healthy subjects.The GP73 level was further compared between liver cirrhosis subgroups by various classification methods.The correlation between GP73 and ALT,AST,ALB,TBIL,PT,and main portal vein diameter was analyzed.Results The GP73 level was significantly higher in the liver cirrhosis group than in the chronic hepatitis group and the healthy control group(P<0.001).Patients with decompensated cirrhosis had a significantly higher serum GP73 level than those with compensated cirrhosis(P<0.001).The serum GP73 levels in the Child-Pugh B and C cirrhosis subgroups were significantly higher than that in the Child-Pugh A cirrhosis subgroup(P<0.05).In the liver cirrhosis group,the GP73 level was positively correlated with AST,ALT,TBIL,PT,and main portal vein diameter,while negatively correlated with ALB.Conclusion Serum GP73 is significantly increased in patients with liver cirrhosis,which is closely related to liver injury indicators.Serum GP73 shows important clinical value for the early diagnosis and prognosis assessment of liver cirrhosis.