基于中医传承计算平台分析肖纯治疗不寐用药规律

Medication Rules of XIAO Chun in Treating Sleepless Based on Traditional Chinese Medicine Inheritance Computing Platform

目的:基于中医传承计算平台(V3.0)探讨肖纯教授治疗不寐的用药规律。方法:收集2015年1月—2021年2月于肖纯教授门诊治疗的不寐患者的病历,依托中医传承计算平台(V3.0),采用关联规则、k均值聚类算法等方法统计分析药物的使用频次,四气、五味、归经频次,药物组合等。结果:纳入590首处方,共使用163味中药,药物总频次11403次。四气:出现频次排在前3位的分别是温性、平性、寒性。五味:出现频次排在前3位的分别是甘味、辛味、苦味。归经:出现频次排在前2位的归经分别是脾经、心经。26味高频药物中,使用频次排在前10位的分别为党参、当归、黄连、酸枣仁、桂枝、干姜、大枣、附子、白术及细辛。药物组合:使用频次排在前3位的分别为党参-当归、党参-黄连、当归-黄连。通过关联规则分析,得到29个高频药物组合以及29条药物核心关联规则,进一步提取出3个核心组合。结论:肖纯教授辨治不寐以调和阴阳为治则,以益气安神、温阳清心兼以活血养血为主要治法。

Objective:To explore the medication rules of Professor XIAO Chun in treating sleepless based on Traditional Chinese Medicine Inheritance Computing Platform(V3.0).Methods:Medical records of sleepless patients treated in Professor XIAO Chun Outpatient Department from January 2015 to February 2021 were collected.Relying on the Traditional Chinese Medicine Inheritance Computing Platform(V3.0),medication rules and K-means clustering algorithm were used to statistically analyze the frequency of herbal use,four natures,five flavors,channel entry and herbal combination.Results:A total of 590 prescriptions were included,and 163 Chinese herbs were used,and the total frequency of herbs was 11403 times.In terms of four natures,the top 3 were warm,mild and cold.In terms of five flavors,the top 3 were sweet,acrid and bitter.In terms of channel entry,the top 2 were the spleen channel and the heart channel.Among the 26 high-frequency herbs,the top 10 were Codonopsis Radix,Angelicae Sinensis Radix,Coptidis Rhizoma,Ziziphi Spinosae Semen,Cinnamomi Ramulus,Zingiberis Rhizoma,Jujubae Fructus,Aconiti Lateralis Radix Praeparata,Atractylodis Macrocephalae Rhizoma and Asari Radix et Rhizoma.In terms of herbal combination,the top 3 were Codonopsis Radix-Angelicae Sinensis Radix,Codonopsis Radix-Coptidis Rhizoma,and Angelicae Sinensis Radix-Coptidis Rhizoma.Through association rule analysis,29 high-frequency herbal combinations and 29 core association rules of herbs were obtained,and 3 core combinations were further extracted.Conclusion:In the syndrome differentiation and treatment of sleepless,Professor XIAO Chun's treatment principle is to harmonize yin and yang,supplemented by the main treatment of boosting qi and calming mind,warming yang and clearing heart heat,and invigorating blood and nourishing blood.