基于肠道菌群理论探讨中医从痰论治阿尔茨海默病

Discussion on Treatment of Alzheimer's Disease from Phlegm in Chinese Medicine Based on Theory of Gut Flora

阿尔茨海默病(AD)是常见的神经退行性疾病。近年来有许多研究表明肠道菌群稳态失调与AD发生发展密切相关。阿尔茨海默病属中医呆病范畴,“痰势最盛,呆气最深”,痰邪正是AD的关键病因。通过梳理肠道菌群、痰邪与AD在病因、发病机制等方面的关联性,阐释肠道菌群失调与痰邪致病理论的相似之处,并总结出健脾疏肝化痰、补肾活血化痰、温阳化痰的主要治法,最后阐述治痰方剂洗心汤、涤痰汤的组方特点及其治疗作用,为中医从痰论治AD提供具有现代科学涵义的理论依据。

Alzheimer's disease(AD)is a common neurodegenerative disease.In recent years,many studies have shown that dyshomeostasis of gut flora is closely related to the development of AD.Alzheimer's disease belongs to the dementia in Chinese medicine,featuring"tendency of phlegm is the most exuberant and degree of dementia is the deepest",and pathogenic phlegm is the etiology of AD.By sorting out the correlation between gut flora,pathogenic phlegm and AD in terms of etiology and pathogenesis,the authors explain the similarities between gut flora disorders and the theory of diseases caused by pathogenic phlegm,and summarize the main treatment methods of fortifying the spleen,soothing the liver and resolving phlegm,tonifying the kidney and activating the blood to resolve phlegm,and warming yang to resolve phlegm.Finally the authors elaborate the characteristics of the prescriptions for treating phlegm,namely,Xixin Decoction and Ditan Decoction,and their curative effects,which provides a theoretical basis with modern scientific meaning for the treatment of AD from phlegm in Chinese medicine.