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PLR和NLR及MHR与慢性肾脏病维持性血液透析患者预后的关系 被引量:2

The relationship between PLR,NLR,MHR and prognosis of maintenance hemodialysis patients with chronic kidney disease
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摘要 目的探究血小板/淋巴细胞比值(PLR)、中性粒细胞/淋巴细胞比值(NLR)、单核细胞/高密度脂蛋白比值(MHR)与慢性肾脏病(CKD)维持性血液透析患者预后的关系。方法选取2020年1月-2022年1月于南阳市中心医院接受维持性血液透析的CKD患者200例为研究对象,所有患者均持续随访至2022年12月,根据患者预后情况分为死亡组(n=43)和存活组(n=157)。比较两组一般临床资料、PLR、NLR和MHR水平,多因素logistic回归分析法分析PLR、NLR、MHR与患者预后的关系,受试者工作特征(ROC)曲线评估PLR、NLR、MHR预测患者预后的价值。结果至随访结束时,43例患者死亡,死亡率为21.50%。死亡组血尿素氮、尿酸、PLR、NLR和MHR水平均明显高于存活组,差异均有统计学意义(t=2.982、2.740、13.090、10.233、6.026,P均<0.01)。多因素logistic回归分析结果显示,PLR、NLR、MHR是影响患者预后的独立危险因素[(OR(95%CI)=3.277(1.733~6.197)、3.323(1.439~7.675)、3.241(1.154~9.106),P均<0.05)]。ROC曲线分析结果显示,PLR、NLR、MHR及其联合检测预测患者预后的曲线下面积分别为0.823、0.800、0.776、0.833(P均<0.05)。结论PLR、NLR、MHR水平与CKD维持性血液透析患者预后相关,对患者预后的评估效能较高,可作为预测患者死亡的独立危险因素。 Objective To explore the relationship between platelet/lymphocyte ratio(PLR),neutrophil/lymphocyte ratio(NLR),monocyte/high-density lipoprotein ratio(MHR)and prognosis of maintenance hemodialysis patients with chronic kidney disease(CKD).Methods A total of 200 patients with CKD who underwent maintenance hemodialysis in the Nanyang Central Hospital from January 2020 and January 2022 were selected as the subjects.All were followed up till December 2022.According to prognosis,they were divided into death group and survival group.The general clinical data,PLR,NLR and MHR were compared between the two groups.The relationship between PLR,NLR,MHR and prognosis was analyzed by multivariate logistic regression analysis.The prognostic value of PLR,NLR and MHR was evaluated by receiver operating characteristic(ROC)curves.Results By the end of follow-up,43(21.50%)patients died.The levels of blood urea nitrogen,uric acid,PLR,NLR and MHR in death group were significantly higher than those in survival group(t=2.982,2.740,13.090,10.233,6.026;all P<0.01).Multivariate logistic regression analysis found that PLR,NLR and MHR were independent risk factors of the prognosis[OR(95%CI)=3.277(1.733-6.197),3.323(1.439-7.675),3.241(1.154-9.106);all P<0.05].ROC curve analysis showed that the area under curve of PLR,NLR,MHR alone and in combination for predicting prognosis were 0.823,0.800,0.776 and 0.833,respectively(all P<0.05).Conclusion PLR,NLR and MHR were correlated with prognosis of CKD patients undergoing maintenance hemodialysis,and were independent risk factors to predict the death.
作者 李攀 刘新宇 李海剑 LI Pan;LIU Xinyu;LI Haijian(Department of Nephrology,Nanyang Central Hospital,Nanyang,Henan 473000,China;Department of Blood Purification,Nanyang Central Hospital,Nanyang,Henan 473000,China;Department of Rheumatology and Immunology,Nanyang Central Hospital,Nanyang,Henan 473000,China)
出处 《热带医学杂志》 CAS 2024年第1期79-82,96,共5页 Journal of Tropical Medicine
基金 河南省科技发展计划项目(212102310811)
关键词 慢性肾脏病 维持性血液透析 血小板/淋巴细胞比值 中性粒细胞/淋巴细胞比值 单核细胞/高密度脂蛋白比值 Chronic kidney disease Maintenance hemodialysis Platelet/lymphocyte ratio Neutrophil/lymphocyte ratio Monocyte/high-density lipoprotein ratio
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