血清胃蛋白酶原和胃泌素-17及PCT联合检测对胃炎的诊断价值

Diagnostic value of combined detection of serum pepsinogen,gastrin-17 and PCT for gastritis

目的探究血清胃蛋白酶原(PG)、胃泌素-17(GAS-17)、降钙素原(PCT)对胃炎的诊断价值。方法选取2020年1月-2022年1月上海健康医学院附属崇明医院收治的胃炎患者102例作为观察组,另选取同期在本院体检的健康者100名作为对照组。采用酶联免疫吸附法(ELISA)检测血清PGⅠ、PGⅡ、GAS-17、PCT水平。采用受试者工作特征(ROC)曲线评价血清PGⅠ、PGⅡ、GAS-17、PCT水平对胃炎的诊断价值;采用多因素logistic回归分析影响胃炎发生的危险因素。结果观察组血清PGⅠ和PGⅠ/PGⅡ比值低于对照组,差异均有统计学意义(t=25.715、21.188,P均<0.05);观察组血清PGⅡ、GAS-17、PCT水平高于对照组,差异均有统计学意义(t=9.575、9.108、34.536,P均<0.05)。ROC曲线分析显示,多指标联合应用诊断胃炎的曲线下面积(AUC)大于血清PGⅠ、PGⅡ、GAS-17、PCT及PGⅠ/PGⅡ比值单独诊断胃炎的AUC,差异均有统计学意义(P均<0.05)。Logistic回归分析结果显示,PGⅠ低表达、PGⅡ高表达、PGⅠ/PGⅡ低比值、GAS-17高表达、PCT高表达均为影响胃炎发生的危险因素(P均<0.05)。结论胃炎患者血清PGⅠ水平和PGⅠ/PGⅡ比值降低,血清PGⅡ、GAS-17、PCT水平升高,各指标均为影响胃炎发生的危险因素;血清PGⅠ、PGⅡ、GAS-17、PCT及PGⅠ/PGⅡ比值联合诊断对胃炎具有较高的诊断价值。

Objective To investigate the diagnostic value of serum pepsinogen(PG),gastrin-17(GAS-17)and procalcitonin(PCT)for gastritis.Methods A total of 102 patients with gastritis admitted to our hospital from January 2020 to January 2022 were regarded as the observation group,another 100 healthy people who were examined in the Chongming Hospital Affiliated to the Shanghai Health Medical College at the same time were regarded as the control group for research.The levels of serum PGⅠ,PGⅡ,GAS-17 and PCT were detected by enzyme-linked immunosorbent assay(ELISA).The diagnostic value of serum PGⅠ,PGⅡ,GAS-17,PCT levels for gastritis was evaluated by the receiver operating characteristic(ROC)curve;multivariate logistic regression was used to analyze the risk factors of gastritis.Results The serum PGⅠlevel and ratio of PGⅠ/PGⅡin the observation group were lower than those in the control group(t=25.715,21.188,all P<0.05);the levels of serum PGⅡ,GAS-17 and PCT in the observation group were higher than those in the control group(t=9.575,9.108,34.536,all P<0.05).ROC curve analysis showed that the area under the curve(AUC)of combined use of multiple indicators in the diagnosis of gastritis was greater than that of serum PGⅠ,PGⅡ,GAS-17,PCT and PGⅠ/PGⅡratio in the separate diagnosis of gastritis(all P<0.05).Logistic regression analysis showed that low expression level of PGⅠ,high expression level of PGⅡ,low ratio of PGⅠ/PGⅡ,high expression level of GAS-17 and high expression level of PCT were all risk factors for gastritis(all P<0.05).Conclusion The level of serum PGⅠand the ratio of PGⅠ/PGⅡin patients with gastritis were decreased,while the levels of serum PGⅡ,GAS-17 and PCT were increased,all of them were risk factors for the occurrence of gastritis;the combination of serum PGⅠ,PGⅡ,GAS-17,PCT and ratio of PGⅠ/PGⅡhad high diagnostic value for gastritis.