人脑类器官在人类病毒感染研究中的应用进展

Application progress of human brain organoid in human virus infection researches

人脑类器官在中枢神经感染研究方面已显示出巨大的前景,并为今后使用人脑类器官进行更精细的研究奠定了基础。人脑类器官已被用来研究寨卡病毒(ZIKV)、严重急性呼吸系统综合征冠状病毒2(SARS-CoV-2)、人类免疫缺陷病毒(HIV)、单纯疱疹病毒1(HSV-1)等多种病毒中枢神经系统发病机制。本综述总结了人脑类器官在建立人类病毒感染模型的研究进展以及它们在新药开发,治疗药物临床前评估平台建设方面的潜在用途。进一步讨论了现有的局限性,并对人脑类器官的发展前景进行了展望。

The human brain organoids have shown a great prospect in the research of central nervous system infection,and laid a foundation for the further study of the use of brain organoids.Human brain organoids have been used to study the pathogenesis of Zika virus(ZIKV),severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),human immunodeficiency virus(HIV),herpes simplex virus-1(HSV-1)and other central nervous system-infected viruses.This review summarized advances in the development of human viral infection models based on the human brain organoids and their potential use in the development of new drugs and in the development of pre-clinical evaluation platforms for therapeutic drugs screening.The existing limitations are discussed,and the development of human brain organoids are prospected.