摘要
截至2022年9月14日,世界卫生组织报告由急性呼吸综合征冠状病毒2(SARS-CoV-2)引起的新型冠状病毒肺炎(COVID-19)(简称新冠肺炎)大流行已蔓延至223个国家和地区,超过6.05亿例确诊病例和640万例死亡病例。此外部分新冠肺炎患者虽然动脉部分氧分压极低,但临床症状轻微,这极大地增加了诊治难度。因此,确定SARS-CoV-2的生物学特性,筛选出新型的、准确度更高的诊断标志物迫在眉睫。近年来,多组学通过高通量检测和分析技术,在揭示疾病特征和辅助疾病诊断方面发挥着重要作用。本文讨论了包括基因组学、转录组学、蛋白质组学和代谢组学在内的多组学在新冠肺炎诊断中的作用,以期为新冠肺炎相关的监测和临床决策提供参考。
As at 14 September 2022,the World Health Organization had reported that the corona virus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),had spread to 223 countries and regions,with over 605 million confirmed cases and 6.4 million deaths.In addition,some patients with COVID-19 have very low arterial partial oxygen pressure,but the clinical symptoms are mild,which greatly increases the difficulty of diagnosis and treatment.Therefore,it is urgent to determine the biological characteristics of SARS-CoV-2 and screen for new and more accurate diagnostic markers.In this review,we discussed the role of multi-omics,including genomics,transcriptomics,proteomics and metabolomics,in the diagnosis of COVID-19,in order to provide reference for the monitoring and clinical decision-making of COVID-19.
作者
姜尧月
赵宝银
李斌
张久聪
李初谊
何昱静
于晓辉
JIANG Yaoyue;ZHAO Baoyin;LI Bin;ZHANG Jiucong;LI Chuyi;HE Yujing;YU Xiaohui(The First Clinical Medical College of Gansu University of Traditional Chinese Medicine,Lanzhou,Gansu 730030,China;Department of Gastroenterology,940 Hospital of the Joint Logistics Support Unit of the Chinese People's Liberation Army,Lanzhou,Gansu 730050,China;The Basic Medical Laboratory,940 Hospital of the Joint Logistics Support Unit of the Chinese People's Liberation Army,the Key Laboratory of Stem Cells And Genetic Drugs of Gansu Province,Lanzhou,Gansu 730050,China)
出处
《热带医学杂志》
CAS
2023年第3期420-424,428,共6页
Journal of Tropical Medicine
基金
甘肃省非感染性肝病临床医学研究中心(21JR7RA017)
甘肃省消化系统重症疾病临床医学研究中心(20JR10RA017)
第九四〇医院院内基金(20yjky020)
火神山医院科研基金面上项目(HSS-217)