佛山市某医院体检人群肝吸虫病的感染概况及临床特点

The infection status and clinical characteristics of Clonorchis sinensis in population having physical examination in a hospital of Foshan city

目的调查体检人群肝吸虫的感染情况和对肝吸虫病的认知情况,分析肝吸虫病患者的临床特征和实验室检查特点。方法选择2020年3月-2021年4月间,在三水区人民医院体检中心健康体检的当地居民2632名,收集粪便,镜检肝吸虫卵;选择符合标准的病例,分为肝吸虫病组和健康对照组,分析其临床症状、实验室检查结果。结果检出肝吸虫感染303例(11.51%),男性感染率(16.87%)明显高于女性(3.58%),差异有统计学意义(χ^(2)=109.749,P<0.05);与其他年龄段相比,40岁以上人群感染率最高,差异有统计学意义(χ^(2)=48.892,P<0.05)。公众对肝吸虫病的知晓率为81.27%,对其危害知晓率为75.76%。肝吸虫病组与健康对照组相比,性别、饮酒史、胆系改变、胆结石、嗜酸性粒细胞(EOS)、谷氨酰转肽酶(GGT)、肝吸虫抗体、胆固醇(CHOL)和甘油三酯(TRIG)的差异均有统计学意义(P均<0.05)。结论公众对肝吸虫病的危害不够重视,需要加大其危害性和防治方法的宣传;提高粪便虫卵检出率,对肝吸虫病早诊断早治疗具有关键作用。

Objective To investigate the infection status of Clonorchis sinensis and the cognition of clonorchiasis inpopulation having physical examination,and the clinical and laboratory characteristics of patients with hepatic fascidiasiswere analyzed.Methods A total of 2632 local residents having physical examination in Sanshui District People’s Hospitalfrom March 2020 to April 2021 were selected,and collect feces,examined under microscope for liver fluke eggs.The caseswere divided into Clonorchis sinensis group and healthy control group,and their clinical symptoms and laboratory resultswere analyzed.Results Among 2632 adult subjects,303 cases(11.51%)were infected with Clonorchis sinensis.Theinfection rate of male(16.87%)was significantly higher than that of female(3.58%)(χ^(2)=109.749,P<0.05).Compared withthe other age groups,infection rates were the highest in people over 40(χ^(2)=48.892,P<0.05).The public awareness rate ofClonorchis sinensis was 81.27%,and the public awareness rate of its hazards was 75.76%.There were statistically significantdifferences in gender,drinking history,biliary changes,gallstones,eosinophils,glutamyl transferase,liver fluke antibody,cholesterol and triglyceride between the Clonorchis sinensis group and the healthy control group(all P<0.05).Conclusions The public was not pay enough attention to the hazards of Clonorchis sinensis infection.The detection rate of fecal worm eggs,treatment of the liver fluke disease and the publicity of the harmness and control of the disease should be improved.