乙酰半胱氨酸辅助治疗肺炎支原体感染的效果及对TARC和IL-6及免疫球蛋白的作用

Effect of acetylcysteine on Mycoplasma pneumoniae infection and its effect on TARC,IL-6 and immunoglobulin

目的探讨乙酰半胱氨酸辅助治疗肺炎支原体感染的效果及对胸腺活化调节趋化因子(TARC)、白细胞介素-6(IL-6)及免疫球蛋白的作用。方法选择2019年1-12月在合肥市第二人民医院接受治疗的80例肺炎支原体感染患儿,采用随机数表法分为研究组(n=40)和对照组(n=40)。对照组给予红霉素、头孢呋辛治疗,研究组加用乙酰半胱氨酸治疗。比较两组临床疗效、血清TARC、IL-6及免疫球蛋白水平变化、临床症状改善及不良反应发生情况。结果治疗后,研究组总有效率92.50%,高于对照组的75.00%,差异有统计学意义(χ^(2)=4.501,P=0.034);治疗后,研究组和对照组TARC、IL-6表达水平均降低,且研究组[(254.14±45.23)ng/L、(6.12±0.51)pg/mL]低于对照组[(303.56±53.24)ng/L、(9.34±0.58)pg/mL],差异均有统计学意义(t=4.474、26.368,P均<0.05)。治疗后,研究组和对照组IgA、IgM及IgG表达水平均降低,且研究组[(1.21±0.14)、(1.41±0.05)、(7.12±0.78)g/L]低于对照组[(1.38±0.23)、(1.49±0.13)、(9.52±0.86)g/L],差异均有统计学意义(t=3.993、3.633、13.074,P均<0.05)。治疗后,研究组临床症状改善时间均显著少于对照组,差异均有统计学意义(t=4.776、4.957、5.333、10.149,P均<0.05);两组不良反应主要为咽痒、呕吐及恶心,差异无统计学意义(P>0.05)。结论在肺炎支原体感染中乙酰半胱氨酸辅助治疗有一定的治疗效果,可能与其改善血清TARC、IL-6及免疫球蛋白有关。

Objective To study effect of acetylcysteine on Mycoplasma pneumoniae infection and its effect on thymus activation regulated chemokine(TARC),interleukin-6(IL-6)and immunoglobulin.Methods 80 patients with Mycoplasma pneumoniae infection treated in the Second People’s Hospital of Hefei from January 2019 to December 2019were selected and divided into study group(n=40)and control group(n=40)by random number table method.The control group was treated with erythromycin and cefuroxime,while the experimental group was treated with acetylcysteine.The clinical efficacy,changes of serum TARC,IL-6 and immunoglobulin levels,improvement of clinical symptoms and occurrence of adverse reactions were compared between the two groups.Results After treatment,the total effective rate of the study group was 92.50%,which was higher than 75.00%of the control group,and the difference was statistically significant(χ^(2)=4.501,P=0.034).After treatment,the levels of TARC and IL-6 in the study group and the control group were decreased,and the levels of TARC and IL-6 in the study group[(254.14±45.23)ng/L,(6.12±0.51)pg/m L]were lower than those in the control group[(303.56±53.24)ng/L,(9.34±0.58)pg/m L];the differences were statistically significant(t=4.474,26.368,all P<0.05).After treatment,the levels of Ig A,Ig M and Ig G decreased in both the study group and the control group.The study group[(1.21±0.14),(1.41±0.05),(7.12±0.78)g/L)]were lower than the control group[(1.38±0.23),(1.49±0.13),(9.52±0.86)g/L];the differences were statistically significant(t=3.993,3.633,13.074,all P<0.05).After treatment,the improvement time of clinical symptoms in the study group were significantly lower than those in the control group,the differences were statistically significant(t=4.776,4.957,5.333,10.149,all P<0.05).The main adverse reactions were itching,vomiting and nausea,and there was no significant difference between the two groups(P>0.05).ConclusionAcetylcysteine had a certain therapeutic effect in Mycoplasma pneumoniae infection,which mightbe related to the improvement of serum TARC,IL-6 and immunoglobulin levels.