血清指标与老年尿毒症感染患者IPS评分的关系及临床意义

The relationship between levels of serum indexes and score of IPS in elderly patients with uremia infection and its clinical significance

目的分析血清胆碱酯酶(ChE)、超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、淀粉样蛋白A(SAA)、D-二聚体(D-D)水平与老年尿毒症感染患者感染可能性评分(IPS)的关系及其临床意义。方法将2021年1月-2022年3月宜兴市人民医院收治的老年尿毒症感染患者40例纳入感染组,另择同期未发生感染的老年尿毒症患者40例作为未感染组,收集两组临床资料。分析两组血清ChE、hs-CRP、PCT、SAA、D-D水平、IPS评分,通过Pearson相关分析法分析血清指标(ChE、hs-CRP、PCT、SAA、D-D)与IPS评分的相关性,并制作散点图。结果感染组血清ChE低于未感染组(t=6.188),血清hs-CRP、PCT、SAA、D-D水平、IPS评分高于未感染组(t=3.904、6.482、7.272、7.397、5.713),差异均有统计学意义(P<0.05)。Pearson相关分析法结果显示,IPS评分与血清hs-CRP、PCT、SAA、D-D水平之间成正相关(r=0.578、0.594、0.658、0.706,P均<0.05),IPS评分与血清ChE水平之间成负相关(r=-0.585,P<0.05)。结论血清hs-CRP、PCT、SAA、D-D水平、IPS评分升高,ChE水平降低与老年尿毒症患者发生感染密切相关,可能作为老年尿毒症感染预测指标及临床治疗的指导依据。

Objective To analyze the relationship between the serum levels of cholinesterase(ChE),high-sensitivity C-reactive protein(hs-CRP),procalcitonin(PCT),serum amyloid A(SAA),D-dimer(D-D)and infection probabilityscore(IPS)in elderly patients with uremia infection and its clinical significance.MethodsA total of 40 elderly patientswith uremia infection who were treated in Yixing People’s Hospital from January 2021 to March 2022 were included in theinfection group,and 40 elderly patients with uremic infection who did not develop infection during the same period wereselected as the uninfected group.Serum levels of Ch E,hs-CRP,PCT,SAA,D-D,and score of IPS of the two groups wereanalyzed,and the correlation between serum indexes(Ch E,hs-CRP,PCT,SAA,D-D)and score of IPS was analyzed byPearson correlation analysis,and the scatter plot was analyzed.ResultsThe serum level of Ch E of the infection group waslower than that of the uninfected group(t=6.188),and the serum levels of hs-CRP,PCT,SAA,D-D and score of IPS werehigher than those of the uninfected group(t=3.904,6.482,7.272,7.397,5.713),the differences were all statisticallysignificant(P<0.05).The results of Pearson correlation analysis showed that there was a positive correlation between scoreof IPS and serum levels of hs-CRP,PCT,SAA and D-D(r=0.578,0.594,0.658,0.706,all P<0.05),and there was anegative correlation between score of IPS and serum level of Ch E(r=-0.585,P<0.05).ConclusionSerum hs-CRP,PCT,SAA,D-D,and IPS scores increased,and Ch E levels decreased,which were closely related to the occurrence ofinfection in elderly uremic patients,and might be used as predictive indicators for elderly uremic infection and guidance forclinical treatment.