结核分枝杆菌早期抗原分泌靶6研究进展

Research progress of Mycobacterium tuberculosis early antigen secretion target 6

结核分枝杆菌早期抗原分泌靶6(ESAT-6)是结核分枝杆菌基因组RD1区基因编码的分泌蛋白,ESAT-6可在细胞膜表面形成孔道导致吞噬体破裂从而介导结核分枝杆菌的免疫逃逸。同时,可用ESAT-6作为抗原进行γ-干扰素释放试验对结核病进行特异性诊断。除此,还探究了ESAT-6在亚单位疫苗中的发展问题,讨论了ESAT-6的作用以及作为亚单位疫苗的可行性。通过对ESAT-6的深入研究,为结核病的防治提供新的方法和思路。

Mycobacterium tuberculosis early secreted antigenic target 6(ESAT-6)is a secreted protein encoded by in the region of difference 1(the region of difference 1)of Mycobacterium tuberculosis genome.ESAT-6 can form pores on host cell membrane surface and cause phagosome rupture of host phagocytes,and mediating the immune escape of Mycobacterium tuberculosis.At the same time,ESAT-6 can be used as an antigen to perform aγ-interferon release test for specific diagnosis of tuberculosis.In addition,this review also summarized the development of ESAT-6 in subunit vaccines,the role of ESAT-6 and its feasibility as a subunit vaccine.The in-depth research on ESAT-6 will provide new methods and ideas for the prevention and treatment of tuberculosis.