4-氨基喹啉类抗疟药在抗病毒感染中的应用

Application of 4-aminoquinoline antimalarial drugs in virus infection

多项体外实验和临床研究表明,经典的喹啉类抗疟药如奎宁、氯喹、羟氯喹、甲氟喹等,除了抗疟原虫的作用外,还具有较广的抗病毒活性,对流感病毒、肝炎病毒、黄热病毒、艾滋病病毒以及冠状病毒感染有一定的作用。本文简述了4-氨基喹啉类抗疟药抗病毒作用的研究现状和临床应用,以期为深入研究和利用抗疟药物抗病毒提供参考。

A number of in vitro experiments and clinical studies have shown that classical quinoline antimalarial drugs such as quinine,chloroquine,hydroxychloroquine,mefloquine,not only have anti-plasmodial effects,but also have a wide range of antiviral effects against influenza virus,hepatitis virus,yellow fever virus,human immunodeficiency virus and coronavirus infections.This review briefly describes the research advances and clinical application of the antiviral effects of 4-aminoquinoline drugs,hoping to provide useful information for in-depth research and utilization of anti-malarial drugs for combating virus infections.